PMID- 16449538
OWN - NLM
STAT- MEDLINE
DCOM- 20060331
LR  - 20181203
IS  - 1060-0280 (Print)
IS  - 1060-0280 (Linking)
VI  - 40
IP  - 2
DP  - 2006 Feb
TI  - Nonconvulsive status epilepticus due to ifosfamide.
PG  - 332-5
AB  - OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following 
      infusion of ifosfamide. CASE SUMMARIES: Two patients who received 
      ifosfamide-containing chemotherapy developed NCSE. One woman received ifosfamide 
      1000 mg/m2 (1 h infusion on days 1-5); confusion, lethargy, and speech 
      deterioration developed on day 3. The second patient developed similar symptoms 
      on day 3 of treatment with 2500 mg/m2. Both patients responded to intravenous 
      administration of diazepam 10 mg and were given levetiracetam as maintenance 
      therapy. DISCUSSION: The severity and presentation of central nervous system 
      toxicity due to ifosfamide varies greatly and involves a spectrum ranging from 
      subclinical electroencephalogram changes to coma. NCSE, an epileptic disorder in 
      which typical convulsive activity is absent, has previously been reported in only 
      4 patients receiving ifosfamide. Levetiracetam may be used for maintenance 
      antiepileptic therapy after diazepam administration. CONCLUSIONS: Among the many 
      presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a 
      possible explanation for changes in consciousness in a patient receiving this 
      agent. An objective causality assessment by use of the Naranjo probability scale 
      revealed that NCSE due to ifosfamide was probable.
FAU - Kilickap, Saadettin
AU  - Kilickap S
AD  - Department of Medical Oncology, Hacettepe University Institute of Oncology, 
      Sihhiye, Ankara, Turkey. skilickap@yahoo.com
FAU - Cakar, Mustafa
AU  - Cakar M
FAU - Onal, Ibrahim K
AU  - Onal IK
FAU - Tufan, Abdurrahman
AU  - Tufan A
FAU - Akoglu, Hadim
AU  - Akoglu H
FAU - Aksoy, Sercan
AU  - Aksoy S
FAU - Erman, Mustafa
AU  - Erman M
FAU - Tekuzman, Gulten
AU  - Tekuzman G
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20060131
PL  - United States
TA  - Ann Pharmacother
JT  - The Annals of pharmacotherapy
JID - 9203131
RN  - 0 (Anticonvulsants)
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 44YRR34555 (Levetiracetam)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - UM20QQM95Y (Ifosfamide)
RN  - ZH516LNZ10 (Piracetam)
SB  - IM
MH  - Anticonvulsants/therapeutic use
MH  - Antineoplastic Agents, Alkylating/administration & dosage/*adverse 
      effects/therapeutic use
MH  - Diazepam/therapeutic use
MH  - Female
MH  - Humans
MH  - Ifosfamide/administration & dosage/*adverse effects/therapeutic use
MH  - Levetiracetam
MH  - Middle Aged
MH  - Neoplasms/drug therapy
MH  - Piracetam/analogs & derivatives/therapeutic use
MH  - Status Epilepticus/*chemically induced/drug therapy
EDAT- 2006/02/02 09:00
MHDA- 2006/04/01 09:00
CRDT- 2006/02/02 09:00
PHST- 2006/02/02 09:00 [pubmed]
PHST- 2006/04/01 09:00 [medline]
PHST- 2006/02/02 09:00 [entrez]
AID - aph.1G363 [pii]
AID - 10.1345/aph.1G363 [doi]
PST - ppublish
SO  - Ann Pharmacother. 2006 Feb;40(2):332-5. doi: 10.1345/aph.1G363. Epub 2006 Jan 31.