PMID- 16451726
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20231103
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 6
DP  - 2006 Feb 1
TI  - The relationship between stage 1 and 2 non-small cell lung cancer and lung 
      function in men and women.
PG  - 2
AB  - BACKGROUND: Reduced forced expiratory volume in one second (FEV1) has been linked 
      to non small cell lung cancer (NSCLC). However, it is unclear whether all or only 
      certain histological subtypes of NSCLC are associated with reduced FEV1. 
      Moreover, there is little information on whether gender modifies this 
      relationship. Using a large tissue registry, we sought to determine the 
      relationship between FEV1 and subtypes of NSCLC and determine whether this 
      relationship is modified by gender. METHODS: We used data from patients who 
      underwent tumor resection for NSCLC at a teaching hospital in Vancouver and had 
      various pre-operative clinical measurements including FEV1. We divided the cohort 
      into quartiles of predicted FEV1 and using both logistic and linear regression 
      modeling techniques determined whether FEV1 was related to the occurrence of 
      adeno or squamous cell carcinoma in men and women. RESULTS: There were 610 
      patients in the study (36% females). On average, women were more likely to have 
      adenocarcinoma than were men (72% of all cases of NSCLC in women versus 40% in 
      men; p < 0.001). In women, there was no significant relationship between FEV1 and 
      the risk of any histological subtypes of NSCLC. In men, however, there was an 
      inverse relationship between the risk of adenocarcinoma and FEV1 such that the 
      lowest quartile of FEV1 was 47% less likely to have adenocarcinoma compared with 
      the highest FEV1 quartile (adjusted odds ratio, 0.52; 0.28 to 0.98; p for trend, 
      0.028). The reverse was observed for squamous cell carcinoma. CONCLUSION: In 
      individuals undergoing lung resection for NSCLC, the risk of adenocarcinoma and 
      squamous cell carcinoma of the lung varies as a function of FEV1, independent of 
      smoking intensity in men but not in women. CLINICAL IMPLICATIONS: These data 
      indicate that women are much more susceptible to adenocarcinoma than are men 
      especially when they have normal or near normal lung function. It may thus be 
      useful to conduct periodic surveillance chest radiographs in asymptomatic female 
      smokers (or ex-smokers) to ascertain peripheral nodules or masses before distant 
      metastases occur since adenocarcinomas tend to metastasize earlier in the disease 
      course than squamous cell carcinomas.
FAU - Malhotra, Samir
AU  - Malhotra S
AD  - Respiratory Division, Department of Medicine, University of British Columbia, 
      British Columbia, Canada. smalhotra@shaw.ca
FAU - Lam, Stephen
AU  - Lam S
FAU - Man, S F Paul
AU  - Man SF
FAU - Gan, Wen Q
AU  - Gan WQ
FAU - Sin, Don D
AU  - Sin DD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060201
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*etiology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Lung/*physiology
MH  - Lung Neoplasms/*etiology
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Staging
MH  - Registries/statistics & numerical data
MH  - Risk Factors
MH  - Sex Factors
MH  - Smoking/adverse effects
PMC - PMC1373665
EDAT- 2006/02/03 09:00
MHDA- 2006/03/22 09:00
PMCR- 2006/02/01
CRDT- 2006/02/03 09:00
PHST- 2005/05/31 00:00 [received]
PHST- 2006/02/01 00:00 [accepted]
PHST- 2006/02/03 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2006/02/03 09:00 [entrez]
PHST- 2006/02/01 00:00 [pmc-release]
AID - 1471-2466-6-2 [pii]
AID - 10.1186/1471-2466-6-2 [doi]
PST - epublish
SO  - BMC Pulm Med. 2006 Feb 1;6:2. doi: 10.1186/1471-2466-6-2.