PMID- 16454800
OWN - NLM
STAT- MEDLINE
DCOM- 20060526
LR  - 20061115
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 18
IP  - 3
DP  - 2006 Mar
TI  - Comparative analysis of immunoreactive cells for androgen receptors and oestrogen 
      receptor alpha in copulating and non-copulating male rats.
PG  - 168-76
AB  - In some species, including gerbils, guinea pigs, mice, rams and rats, some 
      apparently normal males fail to mate. These kinds of animals have been named 
      'noncopulating (NC)'. The cause of this behavioural deficit is unknown. The 
      present study aimed to determine whether NC male rats have alterations in the 
      amount of androgen (AR) and oestrogen receptor alpha (ERalpha) in a neuronal 
      circuit important for the control of male sexual behaviour; the vomeronasal 
      projection pathway. We evaluated the number of AR and ERalpha immunoreactive 
      (AR-IR and ERalpha-IR) cells in the accessory olfactory bulb (AOB), the bed 
      nucleus of the stria terminalis (BNST), the anterior-dorsal medial amygdala 
      (MeAD), the posterior dorsal amygdala (MePD) and the medial preoptic area (MPOA). 
      The results demonstrate that the number of AR-IR cells in NC males was 
      significantly higher compared to copulating (C) males in the MePD, but no 
      significant differences were found in any of the other structures analysed. 
      ERalpha-IR cells were more abundant in NC than in C males in the MeAD and the 
      MePD. However, in the MPOA the number of ERalpha-IR cells was significantly 
      reduced in NC males. No significant differences were found in the AOB or in the 
      BNST. A similar pattern of results was observed when regions within these 
      structures that are activated by Fos expression, on mating or exposure to 
      sexually relevant cues were analysed. The differences in the number of AR and ER 
      in particular brain areas could be associated with alterations in sexual 
      behaviour as well as partner and olfactory preference for receptive females seen 
      in NC male rats.
FAU - Portillo, W
AU  - Portillo W
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, 
      Mexico.
FAU - Diaz, N F
AU  - Diaz NF
FAU - Cabrera, E Antonio
AU  - Cabrera EA
FAU - Fernandez-Guasti, A
AU  - Fernandez-Guasti A
FAU - Paredes, R G
AU  - Paredes RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Receptors, Androgen)
SB  - IM
MH  - Animals
MH  - *Copulation
MH  - Estrogen Receptor alpha/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Orchiectomy
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Androgen/*metabolism
MH  - Sexual Behavior, Animal
EDAT- 2006/02/04 09:00
MHDA- 2006/05/27 09:00
CRDT- 2006/02/04 09:00
PHST- 2006/02/04 09:00 [pubmed]
PHST- 2006/05/27 09:00 [medline]
PHST- 2006/02/04 09:00 [entrez]
AID - JNE1401 [pii]
AID - 10.1111/j.1365-2826.2005.01401.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2006 Mar;18(3):168-76. doi: 10.1111/j.1365-2826.2005.01401.x.