PMID- 16454829
OWN - NLM
STAT- MEDLINE
DCOM- 20060316
LR  - 20161124
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 101
IP  - 2
DP  - 2006 Feb
TI  - Prospective endoscopic ultrasonographic evaluation of the frequency of 
      nonfunctioning pancreaticoduodenal endocrine tumors in patients with multiple 
      endocrine neoplasia type 1.
PG  - 266-73
AB  - BACKGROUND: The frequency of pancreaticoduodenal endocrine tumors in patients 
      with multiple endocrine neoplasia type 1 (MEN1) remains unknown. AIM: To evaluate 
      prospectively with endoscopic ultrasonography (EUS) the frequency of 
      nonfunctioning (asymptomatic) pancreaticoduodenal tumors. PATIENTS AND METHODS: 
      MEN1 patients without functioning pancreatic involvement underwent systematic 
      pancreaticoduodenal EUS in nine GTE (Groupe des Tumeurs Endocrines) centers. 
      Demographic and clinical factors predictive of pancreatic involvement were 
      sought, and standardized biochemical measurements obtained. RESULTS: Between 
      November 1997 and July 2004, 51 patients (median age: 39 [range: 16-71] yr) were 
      studied. MEN1 had been diagnosed 3 [0-20] yr earlier, notably by genetic 
      screening for 26 (51%) with asymptomatic disease. Twenty-five patients had minor 
      biochemical anomalies (<2 x normal (N)) and serum somatostatin was 10.8 N in 1; 
      EUS detected pancreatic lesions in 28 patients (54.9%; 95% CI: 41.3-68.7%). A 
      median of three [1-9] tumors with a median diameter of 6 [2-60] mm was found per 
      patient; for 19 (37.3%) patients a tumor measured > or =10 mm and > or = 20 mm in 
      7 (13.7%) patients. Only one duodenal lesion was found and three patients had 
      peripancreatic adenopathies. Pancreatic tumors were not associated with any of 
      the studied parameters, notably age, family history, biochemical anomalies. 
      Sixteen of twenty-six patients underwent EUS monitoring over 50 [12-70] months; 
      six (37.5%) had more and/or larger pancreatic lesions. CONCLUSION: The frequency 
      of nonfunctioning pancreatic endocrine tumors is higher (54.9%) than previously 
      thought. The size and number of these tumors can increase over time. Pancreatic 
      EUS should be performed once MEN1 is diagnosed to monitor disease progression.
FAU - Thomas-Marques, Laurence
AU  - Thomas-Marques L
AD  - Gastroenterology, Hopital Robert Debre, CHU de Reims, France.
FAU - Murat, Arnaud
AU  - Murat A
FAU - Delemer, Brigitte
AU  - Delemer B
FAU - Penfornis, Alfred
AU  - Penfornis A
FAU - Cardot-Bauters, Catherine
AU  - Cardot-Bauters C
FAU - Baudin, Eric
AU  - Baudin E
FAU - Niccoli-Sire, Patricia
AU  - Niccoli-Sire P
FAU - Levoir, Damien
AU  - Levoir D
FAU - Choplin, Helene du Boullay
AU  - Choplin Hdu B
FAU - Chabre, Olivier
AU  - Chabre O
FAU - Jovenin, Nicolas
AU  - Jovenin N
FAU - Cadiot, Guillaume
AU  - Cadiot G
CN  - Groupe des Tumeurs Endocrines (GTE)
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Gastrins)
RN  - 0 (Peptides)
RN  - 0 (polypeptide C)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 59763-91-6 (Pancreatic Polypeptide)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/blood
MH  - Diagnosis, Differential
MH  - Disease Progression
MH  - Duodenal Neoplasms/blood/*diagnostic imaging/epidemiology
MH  - *Endosonography
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrins/blood
MH  - Glucagon/blood
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/blood/*diagnostic imaging
MH  - Pancreatic Neoplasms/blood/*diagnostic imaging/epidemiology
MH  - Pancreatic Polypeptide/blood
MH  - Peptides/blood
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Vasoactive Intestinal Peptide/blood
EDAT- 2006/02/04 09:00
MHDA- 2006/03/17 09:00
CRDT- 2006/02/04 09:00
PHST- 2006/02/04 09:00 [pubmed]
PHST- 2006/03/17 09:00 [medline]
PHST- 2006/02/04 09:00 [entrez]
AID - AJG367 [pii]
AID - 10.1111/j.1572-0241.2006.00367.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2006 Feb;101(2):266-73. doi: 
      10.1111/j.1572-0241.2006.00367.x.