PMID- 16455376
OWN - NLM
STAT- MEDLINE
DCOM- 20060315
LR  - 20061115
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 134
IP  - 2
DP  - 2006 Feb
TI  - Diffuse mucosal inflammation in nasal polyps and adjacent middle turbinate.
PG  - 267-75
AB  - BACKGROUND: Nasal polyp (NP) is the most common mass lesion in the nose with 
      unclear etiology and pathogenesis. OBJECTIVE: To investigate the association of 
      allergy and type of cellular inflammation in Asian patients with NPs. METHODS: 
      Immunohistochemical staining with a panel of antibodies for CD4+ and CD8+ T 
      cells, B cells, Langerhans' cells, eosinophils, neutrophils, and mast cells were 
      performed in pairs of NP tissue and middle turbinate (MT) biopsies from the same 
      side of 48 patients and MT of controls. Serum total IgE and specific IgE to a 
      panel of common local allergens were tested by the UniCAP (Pharmacia & Upjohn AB, 
      Uppsala, Sweden) system. RESULTS: Atopy was found in 29.7% of NP patients. Strong 
      correlations of cell scores were evidenced between the paired samples from nasal 
      polyp patients. The cell patterns in nasal polyp mainly showed a combined cell 
      infiltration with significantly higher CD8+ T cell, eosinophil and neutrophil 
      scores, and an inverse median ratio of CD4+/CD8+ T cells as compared with the MT 
      from controls. CONCLUSION: The similar immunohistochemical pattern of mucosal 
      inflammation in NPs and the paired MT mucosa suggests a diffuse mucosal 
      involvement. This indicates the necessity of anti-inflammatory treatment of 
      changes in the adjacent nasal mucosa in addition to the surgical removal of NPs. 
      Besides the well-recognized eosinophilic inflammation in Caucasian studies, 
      predominant infiltration of T cells, especially CD8+ T cells, could be a key 
      component underlying the pathogeneses of NPs.
FAU - Hao, Jing
AU  - Hao J
AD  - Department of Otolaryngology, Faculty of Medicine, National University of 
      Singapore, Singapore.
FAU - Pang, Yoke-Teen
AU  - Pang YT
FAU - Wang, De-Yun
AU  - Wang DY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - CD4-Positive T-Lymphocytes/metabolism
MH  - CD8-Positive T-Lymphocytes/metabolism
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Nasal Mucosa/cytology/*pathology
MH  - Nasal Polyps/*pathology
MH  - Prospective Studies
MH  - Turbinates/metabolism/*pathology
EDAT- 2006/02/04 09:00
MHDA- 2006/03/16 09:00
CRDT- 2006/02/04 09:00
PHST- 2004/09/15 00:00 [received]
PHST- 2006/02/04 09:00 [pubmed]
PHST- 2006/03/16 09:00 [medline]
PHST- 2006/02/04 09:00 [entrez]
AID - S0194-5998(05)01901-7 [pii]
AID - 10.1016/j.otohns.2005.09.026 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2006 Feb;134(2):267-75. doi: 
      10.1016/j.otohns.2005.09.026.