PMID- 16455593
OWN - NLM
STAT- MEDLINE
DCOM- 20060718
LR  - 20191109
IS  - 0148-0545 (Print)
IS  - 0148-0545 (Linking)
VI  - 29
IP  - 1
DP  - 2006 Jan
TI  - Hematological and clinical chemistry changes induced by subchronic dosing of a 
      novel phosphorothionate (RPR-V) in Wistar male and female rats.
PG  - 95-110
AB  - A novel phosphorothionate [2-butenoic acid-3-(diethoxy phosphinothioyl)-ethyl 
      ester; RPR-V] synthesized at Indian Institute of Chemical Technology (Hyderabad, 
      India) was studied using subchronic doses of 0.033 (low), 0.066 (medium), and 
      0.099 (high) mg kg(- 1) in male and female rats daily for 90 days. Continuous 
      treatment with RPR-V caused significant (p < 0.05) decreases in body-weight gain, 
      feed intake, hemoglobin (Hb), hematocrit (Hct), and total erythrocyte count 
      (TEC), whereas total leukocyte count (TLC), mean corpuscular volume (MCV), mean 
      corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration 
      (MCHC) were increased. Similarly, RPR-V caused significant elevation in serum 
      clinical chemistry parameters calcium, phosphorus, creatinine, and chloride 
      contents, whereas protein and glucose levels were depressed in both male and 
      female treated rats after 45 and 90 days of treatment. These alterations were 
      significant when compared with two-way ANOVA showing that these changes were 
      dose- and time-dependent. The effects of low dose were generally not 
      statistically significant, whereas medium and high doses caused significant 
      effects. The changes in male rats were not significant when compared with female 
      rats showing no sexual dimorphism by this compound. Recovery was observed after 
      28 days post-treatment (withdrawal study), indicating that the compound entered 
      into the system was eliminated from the body, and the blood parameters were 
      improved. Hematological and clinical chemistry parameters can be detected rapidly 
      and hence can be used for prediction and diagnosis of pesticide toxicity. 
      Alterations in these parameters show toxic stress in the treated animals 
      especially on blood and blood-forming organs.
FAU - Rahman, M F
AU  - Rahman MF
AD  - Biochemical Toxicology, Biology Division, Indian Institute of Chemical 
      Technology, Hyderabad, India. rahman_m_f@yahoo.co.in
FAU - Siddiqui, M K J
AU  - Siddiqui MK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Drug Chem Toxicol
JT  - Drug and chemical toxicology
JID - 7801723
RN  - 0 (Insecticides)
RN  - 0 (Sulfhydryl Compounds)
RN  - 128606-47-3 (RPR 5)
RN  - 6923-22-4 (Monocrotophos)
SB  - IM
MH  - Animals
MH  - Blood/*drug effects
MH  - Blood Chemical Analysis
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - Erythrocytes/chemistry/drug effects/pathology
MH  - Female
MH  - Hematologic Tests
MH  - Hematopoiesis/*drug effects
MH  - Insecticides/*toxicity
MH  - Leukocytes/drug effects/pathology
MH  - Male
MH  - Monocrotophos/*analogs & derivatives/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Sulfhydryl Compounds/*toxicity
MH  - Weight Gain/drug effects
EDAT- 2006/02/04 09:00
MHDA- 2006/07/19 09:00
CRDT- 2006/02/04 09:00
PHST- 2006/02/04 09:00 [pubmed]
PHST- 2006/07/19 09:00 [medline]
PHST- 2006/02/04 09:00 [entrez]
AID - G74511577181X1RV [pii]
AID - 10.1080/01480540500408697 [doi]
PST - ppublish
SO  - Drug Chem Toxicol. 2006 Jan;29(1):95-110. doi: 10.1080/01480540500408697.