PMID- 16455884
OWN - NLM
STAT- MEDLINE
DCOM- 20060418
LR  - 20221207
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 44
IP  - 2
DP  - 2006 Feb
TI  - Epidemiological and genetic correlates of severe acute respiratory syndrome 
      coronavirus infection in the hospital with the highest nosocomial infection rate 
      in Taiwan in 2003.
PG  - 359-65
AB  - Taiwan experienced a series of outbreaks of nosocomial severe acute respiratory 
      syndrome (SARS) infections in 2003. Two months after the final outbreak, we 
      recruited 658 employees from the hospital that suffered the first and most severe 
      SARS infections to help us investigate epidemiological and genetic factors 
      associated with the SARS coronavirus (SARS-CoV). SARS-CoV infections were 
      detected by using enzyme immunoassays and confirmed by a combination of Western 
      blot assays, neutralizing antibody tests, and commercial SARS tests. Risk factors 
      were analyzed via questionnaire responses and sequence-specific oligonucleotide 
      probes of human leukocyte antigen (HLA) alleles. Our results indicate that 3% 
      (20/658) of the study participants were seropositive, with one female nurse 
      identified as a subclinical case. Identified SARS-CoV infection risk factors 
      include working in the same building as the hospital's emergency room and 
      infection ward, providing direct care to SARS patients, and carrying a Cw*0801 
      HLA allele. The odds ratio for contracting a SARS-CoV infection among persons 
      with either a homozygous or a heterozygous Cw*0801 genotype was 4.4 (95% 
      confidence interval, 1.5 to 12.9; P = 0.007).
FAU - Chen, Yi-Ming Arthur
AU  - Chen YM
AD  - Institute of Public Health, National Yang-Ming University, Li-Noun Street, 
      Section 2, Taipei, Taiwan. arthur@ym.edu.tw
FAU - Liang, Shu-Yuan
AU  - Liang SY
FAU - Shih, Yi-Ping
AU  - Shih YP
FAU - Chen, Chia-Yen
AU  - Chen CY
FAU - Lee, Yuan-Ming
AU  - Lee YM
FAU - Chang, Ling
AU  - Chang L
FAU - Jung, Shiao-Ying
AU  - Jung SY
FAU - Ho, Mei-Shang
AU  - Ho MS
FAU - Liang, Kung-Yee
AU  - Liang KY
FAU - Chen, Hour-Young
AU  - Chen HY
FAU - Chan, Yu-Jiun
AU  - Chan YJ
FAU - Chu, Da-Chen
AU  - Chu DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Blotting, Western
MH  - Cross Infection/*epidemiology/virology
MH  - Disease Outbreaks
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA-C Antigens/*genetics
MH  - Histocompatibility Testing
MH  - *Hospitals, Urban
MH  - Humans
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - Neutralization Tests
MH  - Risk Factors
MH  - Severe acute respiratory syndrome-related coronavirus/*immunology
MH  - Severe Acute Respiratory Syndrome/*epidemiology/*genetics/virology
MH  - Surveys and Questionnaires
MH  - Taiwan/epidemiology
PMC - PMC1392693
EDAT- 2006/02/04 09:00
MHDA- 2006/04/19 09:00
PMCR- 2006/06/01
CRDT- 2006/02/04 09:00
PHST- 2006/02/04 09:00 [pubmed]
PHST- 2006/04/19 09:00 [medline]
PHST- 2006/02/04 09:00 [entrez]
PHST- 2006/06/01 00:00 [pmc-release]
AID - 44/2/359 [pii]
AID - 1997-05 [pii]
AID - 10.1128/JCM.44.2.359-365.2006 [doi]
PST - ppublish
SO  - J Clin Microbiol. 2006 Feb;44(2):359-65. doi: 10.1128/JCM.44.2.359-365.2006.