PMID- 16456803 OWN - NLM STAT- MEDLINE DCOM- 20060410 LR - 20221207 IS - 1003-9406 (Print) IS - 1003-9406 (Linking) VI - 23 IP - 1 DP - 2006 Feb TI - [HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing]. PG - 103-6 AB - OBJECTIVE: To investigate the gene polymorphism of human leukocyte antigen (HLA)-A, B, DRB1 loci in the population of Beijing region, and research on the application feasibility of polymerase chain reaction sequence-based typing (PCR-SBT) method. METHODS: PCR-SBT method was applied to determine HLA- A, B, DRB1 genotypes of 618 unrelated healthy individuals of Beijing region. RESULTS: A total of 84 different alleles and 199 genotypes of HLA-A, 143 alleles and 366 genotypes of HLA-B, 122 alleles and 286 genotypes of HLA-DRB1 were detected. CONCLUSION: The results showed the characteristics of HLA-A, B, DRB1 distributions, and provided more comprehensive and accurate gene data that may serve as normal reference values for all of Beijing people. FAU - Deng, Ya-jun AU - Deng YJ AD - Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, P.R.China. FAU - Yang, Guang AU - Yang G FAU - Wu, Dong-ying AU - Wu DY FAU - Hu, Song-nian AU - Hu SN FAU - Li, Sheng-bin AU - Li SB FAU - Zhu, Jun AU - Zhu J FAU - Zhu, Bo-feng AU - Zhu BF FAU - Liu, Yao AU - Liu Y LA - chi PT - Journal Article PL - China TA - Zhonghua Yi Xue Yi Chuan Xue Za Zhi JT - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JID - 9425197 RN - 0 (HLA-A Antigens) RN - 0 (HLA-B Antigens) RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB1 Chains) SB - IM MH - Asian People/*genetics MH - China/ethnology MH - Female MH - Genetics, Population MH - HLA-A Antigens/*genetics MH - HLA-B Antigens/*genetics MH - HLA-DR Antigens/*genetics MH - HLA-DRB1 Chains MH - Humans MH - Male MH - Polymerase Chain Reaction MH - *Polymorphism, Genetic MH - Population EDAT- 2006/02/04 09:00 MHDA- 2006/04/11 09:00 CRDT- 2006/02/04 09:00 PHST- 2006/02/04 09:00 [pubmed] PHST- 2006/04/11 09:00 [medline] PHST- 2006/02/04 09:00 [entrez] AID - 940623028 [pii] PST - ppublish SO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Feb;23(1):103-6.