PMID- 16457806
OWN - NLM
STAT- MEDLINE
DCOM- 20060418
LR  - 20131121
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 531
IP  - 1-3
DP  - 2006 Feb 15
TI  - (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic 
      system in the brain.
PG  - 171-5
AB  - (-)-Epigallocatechin gallate (EGCG), a flavonoid, is the principal catechin found 
      in green tea and is distributed in the brain after tea consumption. The aim of 
      the present study was to investigate the effects of EGCG in the chick brain under 
      an acute stressful condition and to clarify the mechanism by which EGCG 
      attenuates stress behavior with special reference to gamma-aminobutyric acid 
      (GABA). Intracerebroventricular (i.c.v.) injection of EGCG (50, 100 and 200 
      microg) suppressed the vocalization which normally occurs during social 
      separation stress. EGCG decreased the time spent in active wakefulness and 
      induced sleep-like behavior in a dose-dependent manner. Additionally, i.c.v. 
      injection of EGCG attenuated plasma corticosterone release under social 
      separation stress. These effects of EGCG on distress-induced vocalization were 
      significantly attenuated by the GABAA receptor antagonist picrotoxin but not by 
      the GABAB receptor antagonist CGP 54626 
      (3-N-(1-(3,4-dichlorophenyl)ethylamino)-2-hydroxypropyl cyclohexylmethyl 
      phosphinic acid hydrochloride). These results indicate that EGCG has sedative and 
      hypnotic effects in the brain, partially through GABAA receptors, and 
      consequently moderates an acute stress response.
FAU - Adachi, Nami
AU  - Adachi N
AD  - Laboratory of Advanced Animal and Marine Bioresources, Graduate School of 
      Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, 
      Japan.
FAU - Tomonaga, Shozo
AU  - Tomonaga S
FAU - Tachibana, Tetsuya
AU  - Tachibana T
FAU - Denbow, D Michael
AU  - Denbow DM
FAU - Furuse, Mitsuhiro
AU  - Furuse M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060202
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antioxidants)
RN  - 0 (GABA Antagonists)
RN  - 0 (GABA-B Receptor Antagonists)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Receptors, GABA-B)
RN  - 124-87-8 (Picrotoxin)
RN  - 149184-21-4 (CGP 54626)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antioxidants/administration & dosage/pharmacology
MH  - Brain/*drug effects/physiology/physiopathology
MH  - Catechin/administration & dosage/*analogs & derivatives/pharmacology
MH  - Chickens
MH  - Corticosterone/blood
MH  - Dose-Response Relationship, Drug
MH  - GABA Antagonists/pharmacology
MH  - GABA-B Receptor Antagonists
MH  - Injections, Intraventricular
MH  - Male
MH  - Organophosphorus Compounds/pharmacology
MH  - Picrotoxin/pharmacology
MH  - Receptors, GABA-B/*physiology
MH  - Stress, Psychological/physiopathology/*prevention & control
MH  - Vocalization, Animal/drug effects
EDAT- 2006/02/07 09:00
MHDA- 2006/04/19 09:00
CRDT- 2006/02/07 09:00
PHST- 2005/06/27 00:00 [received]
PHST- 2005/12/14 00:00 [revised]
PHST- 2005/12/16 00:00 [accepted]
PHST- 2006/02/07 09:00 [pubmed]
PHST- 2006/04/19 09:00 [medline]
PHST- 2006/02/07 09:00 [entrez]
AID - S0014-2999(05)01326-9 [pii]
AID - 10.1016/j.ejphar.2005.12.024 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2006 Feb 15;531(1-3):171-5. doi: 10.1016/j.ejphar.2005.12.024. 
      Epub 2006 Feb 2.