PMID- 16457985
OWN - NLM
STAT- MEDLINE
DCOM- 20060628
LR  - 20240408
IS  - 0892-0362 (Print)
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Linking)
VI  - 28
IP  - 2
DP  - 2006 Mar-Apr
TI  - Perinatal ethanol exposure alters met-enkephalin levels of male and female rats.
PG  - 238-44
AB  - This study used a rat model of Fetal Alcohol Syndrome to investigate whether 
      combined prenatal and postnatal ethanol exposure affects met-enkephalin levels in 
      the brains of male and female Long-Evans adult rats. Intragastric ethanol was 
      administered to a group of rats (ET) from gestational day (GD) 1 through 22 and 
      from postnatal day (PD) 2 through 10. The control groups consisted of a 
      nontreated control group (NTC) and an intubated control group (IC) that received 
      the intragastric intubation procedure but no exposure to ethanol. We measured 
      met-enkephalin levels in the prefrontal cortex, nucleus accumbens, hypothalamus, 
      central and basolateral nucleus of amygdala and ventral tegmental area. 
      Met-enkephalin levels in the hypothalamus of male and female ET animals were 
      significantly higher than those in either the NTC or IC animals. Met-enkephalin 
      levels in the central nucleus of the amygdala of male and female ET animals were 
      significantly lower than the levels in the NTC animals. Met-enkephalin levels in 
      the nucleus accumbens of ET females were significantly greater than those in the 
      IC females. These results demonstrate that the combination of prenatal and 
      postnatal ethanol exposure affects basal met-enkephalin levels in specific 
      regions in a sex-specific manner. These changes in met-enkephalin levels may 
      explain how early ethanol exposure affects opioid-regulated behaviors such as 
      social play, sexual behavior, and other social behaviors.
FAU - Lugo, Joaquin N Jr
AU  - Lugo JN Jr
AD  - Department of Psychology, University of South Carolina, Columbia, SC 29208, USA. 
      jlugo@bcm.tmc.edu
FAU - Wilson, Marlene A
AU  - Wilson MA
FAU - Kelly, Sandra J
AU  - Kelly SJ
LA  - eng
GR  - AA05583/AA/NIAAA NIH HHS/United States
GR  - F31 AA005583/AA/NIAAA NIH HHS/United States
GR  - R01 AA11566/AA/NIAAA NIH HHS/United States
GR  - R01 MH63344/MH/NIMH NIH HHS/United States
GR  - R01 MH063344/MH/NIMH NIH HHS/United States
GR  - R01 AA011566/AA/NIAAA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060202
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
RN  - 58569-55-4 (Enkephalin, Methionine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Birth Weight/drug effects
MH  - Brain/*drug effects/embryology/growth & development/metabolism
MH  - Brain Chemistry/drug effects
MH  - Central Nervous System Depressants/*administration & dosage/blood
MH  - Disease Models, Animal
MH  - Drug Administration Routes
MH  - Enkephalin, Methionine/*metabolism
MH  - Ethanol/*administration & dosage/blood
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/etiology/metabolism
MH  - Gestational Age
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Long-Evans
MH  - *Sex Characteristics
PMC - PMC3596822
MID - NIHMS448035
EDAT- 2006/02/07 09:00
MHDA- 2006/06/29 09:00
PMCR- 2013/03/14
CRDT- 2006/02/07 09:00
PHST- 2005/07/11 00:00 [received]
PHST- 2005/12/03 00:00 [revised]
PHST- 2005/12/05 00:00 [accepted]
PHST- 2006/02/07 09:00 [pubmed]
PHST- 2006/06/29 09:00 [medline]
PHST- 2006/02/07 09:00 [entrez]
PHST- 2013/03/14 00:00 [pmc-release]
AID - S0892-0362(05)00182-0 [pii]
AID - 10.1016/j.ntt.2005.12.004 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2006 Mar-Apr;28(2):238-44. doi: 10.1016/j.ntt.2005.12.004. 
      Epub 2006 Feb 2.