PMID- 16458884
OWN - NLM
STAT- MEDLINE
DCOM- 20061017
LR  - 20061115
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 102
IP  - 1
DP  - 2006 Sep
TI  - Exposure to persistent organic pollutants and hypertensive disease.
PG  - 101-6
AB  - Previous research suggests that exposure to persistent organic pollutants (POPs) 
      increases the risk of chronic diseases such as hypertension. We identified the 
      zip codes of more than 800 waste sites contaminated with POPs and other 
      pollutants, based on which we classified zip codes of upstate New York into three 
      groups: "POPs sites", zip codes containing hazardous waste sites with POPs; 
      "other waste sites", zip codes containing hazardous waste sites but not with 
      POPs; and "clean sites", zip codes without any known hazardous waste sites. Age, 
      gender, race, and zip code of residence of patients diagnosed with hypertension 
      (ICD-9 codes 401-404) were identified using the New York Statewide Planning and 
      Research Cooperative System (SPARCS) for the years 1993-2000. A generalized 
      linear model, the negative binomial model, was used to assess the effect of 
      living in a zip code with a hazardous waste site on the discharge rate of 
      hypertension. After control for the aforementioned covariates, we found a 
      statistically significant elevation of 19.2% (95% CI = 8.5%, 31%) in hypertension 
      discharge rate for "POPs sites" and a 10% elevation in discharge rates for "other 
      waste sites" as compared to "clean sites". In a subset of "POPs sites" where 
      people have higher income, smoke less, exercise more and have healthier diets, 
      there was still a 13.9% elevation of hypertension discharge rate as compared to 
      "clean sites". The results support the hypothesis that living near hazardous 
      waste sites, particularly sites containing POPs, may constitute a risk of 
      exposure and of developing hypertension.
FAU - Huang, Xiaoyu
AU  - Huang X
AD  - Department of Biometry and Statistics, School of Public Health, University at 
      Albany, SUNY, One University Place, Rm. 131, Rensselaer, NY 12144, USA.
FAU - Lessner, Lawrence
AU  - Lessner L
FAU - Carpenter, David O
AU  - Carpenter DO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060203
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Hazardous Waste)
RN  - 0 (Hydrocarbons, Halogenated)
SB  - IM
MH  - Adult
MH  - Air Pollutants/*poisoning
MH  - Binomial Distribution
MH  - Female
MH  - Hazardous Waste/*adverse effects
MH  - Humans
MH  - Hydrocarbons, Halogenated/*poisoning
MH  - Hypertension/*chemically induced/epidemiology
MH  - Inhalation Exposure/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - New York/epidemiology
MH  - Regression Analysis
MH  - Socioeconomic Factors
EDAT- 2006/02/07 09:00
MHDA- 2006/10/18 09:00
CRDT- 2006/02/07 09:00
PHST- 2005/09/15 00:00 [received]
PHST- 2005/12/06 00:00 [revised]
PHST- 2005/12/12 00:00 [accepted]
PHST- 2006/02/07 09:00 [pubmed]
PHST- 2006/10/18 09:00 [medline]
PHST- 2006/02/07 09:00 [entrez]
AID - S0013-9351(05)00200-8 [pii]
AID - 10.1016/j.envres.2005.12.011 [doi]
PST - ppublish
SO  - Environ Res. 2006 Sep;102(1):101-6. doi: 10.1016/j.envres.2005.12.011. Epub 2006 
      Feb 3.