PMID- 16460767
OWN - NLM
STAT- MEDLINE
DCOM- 20060804
LR  - 20131121
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 79
IP  - 3
DP  - 2006 Jun 13
TI  - Effects of mood stabilizers on hippocampus BDNF levels in an animal model of 
      mania.
PG  - 281-6
AB  - There is an emerging body of data suggesting that mood disorders are associated 
      with decreased brain-derived neurotrophic factor (BDNF). The present study aims 
      to investigate the effects of the mood stabilizers lithium (Li) and valproate 
      (VPT) in an animal model of bipolar disorder. In the first experiment (acute 
      treatment), rats were administered D-amphetamine (AMPH) or saline for 14 days, 
      and then between day 8 and 14, rats were treated with either Li, VPT or saline. 
      In the second experiment (maintenance treatment), rats were pretreated with Li, 
      VPT or saline, and then between day 8 and 14, rats were administered AMPH or 
      saline. In both experiments, locomotor activity was measured using the open-field 
      test and BDNF levels were measured in rat hippocampus by sandwich-ELISA. Li and 
      VPT reversed AMPH-induced behavioral effects in the open-field test in both 
      experiments. In the first experiment, Li increased BDNF levels in rat 
      hippocampus. In the second experiment, AMPH decreased BDNF levels and Li and VPT 
      increased BDNF levels in rat hippocampus. Our results suggest that the present 
      model fulfills adequate face, construct and predictive validity as an animal 
      model of mania.
FAU - Frey, Benicio N
AU  - Frey BN
AD  - Department of Biochemistry, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600/Anexo, Zip code: 
      90035-003, Porto Alegre, RS, Brazil.
FAU - Andreazza, Ana C
AU  - Andreazza AC
FAU - Cereser, Keila M M
AU  - Cereser KM
FAU - Martins, Marcio R
AU  - Martins MR
FAU - Valvassori, Samira S
AU  - Valvassori SS
FAU - Reus, Gislaine Z
AU  - Reus GZ
FAU - Quevedo, Joao
AU  - Quevedo J
FAU - Kapczinski, Flavio
AU  - Kapczinski F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060207
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Antimanic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 9FN79X2M3F (Lithium)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Affect/drug effects
MH  - Amphetamine/antagonists & inhibitors/toxicity
MH  - Animals
MH  - Antimanic Agents/*administration & dosage
MH  - Bipolar Disorder/chemically induced/*drug therapy
MH  - Brain-Derived Neurotrophic Factor/analysis/*metabolism
MH  - *Disease Models, Animal
MH  - Hippocampus/drug effects/*metabolism
MH  - Lithium/*administration & dosage
MH  - Male
MH  - Rats/*metabolism
MH  - Rats, Wistar
MH  - Valproic Acid/*administration & dosage
EDAT- 2006/02/08 09:00
MHDA- 2006/08/05 09:00
CRDT- 2006/02/08 09:00
PHST- 2005/10/22 00:00 [received]
PHST- 2005/11/29 00:00 [revised]
PHST- 2006/01/04 00:00 [accepted]
PHST- 2006/02/08 09:00 [pubmed]
PHST- 2006/08/05 09:00 [medline]
PHST- 2006/02/08 09:00 [entrez]
AID - S0024-3205(06)00030-0 [pii]
AID - 10.1016/j.lfs.2006.01.002 [doi]
PST - ppublish
SO  - Life Sci. 2006 Jun 13;79(3):281-6. doi: 10.1016/j.lfs.2006.01.002. Epub 2006 Feb 
      7.