PMID- 1646103
OWN - NLM
STAT- MEDLINE
DCOM- 19910718
LR  - 20190827
IS  - 0425-1644 (Print)
IS  - 0425-1644 (Linking)
VI  - 23
IP  - 2
DP  - 1991 Mar
TI  - The raising of equine colostrum-deprived foals; maintenance and assessment of 
      specific pathogen (EHV-1/4) free status.
PG  - 111-5
AB  - Over a period of two years, a total of 22 full term foals from Welsh Mountain 
      pony mares were raised in conditions that were free from infection by Equid 
      herpesvirus (EHV-1/4). Parturition dates were predicted by monitoring colostrum 
      electrolytes, and the mares allowed to foal naturally under supervision or 
      following induction with intravenous oxytocin. Immediately following birth, foals 
      were separated from their dams and transferred to a specially built, positive 
      pressure isolation unit. They were given antibiotic prophylaxis and fed bovine 
      colostrum during the first 24 h, and then mare's milk replacer until weaned. Out 
      of 22 specific pathogen free (SPF) foals one that had not been given antibiotic 
      prophylaxis died of an E. coli septicaemia aged eight days. Two foals developed a 
      streptococcal upper respiratory tract infection, which responded to antibiotic 
      therapy and did not spread to the rest of the herd. A self limiting upper 
      respiratory tract infection was seen in a fourth foal and mild diarrhoea was 
      observed in six foals. Physical development in all SPF foals appeared normal and 
      behavioural patterns resembled those of conventional handreared foals. Newborn 
      foals were held in a separate quarantine area, within the isolation unit, and 
      checked extensively for evidence of EHV-1/4 infection, before being transferred 
      to the main holding unit. Periodic checks were then made for EHV-1/4 over a 
      period ranging from 2 to 4 months; none of the SPF foals showed evidence of 
      infection with EHV-1/4 in terms of clinical disease, virus isolation, 
      sero-conversion or specific lymphocyte transformation.
FAU - Chong, Y C
AU  - Chong YC
AD  - Department of Clinical Veterinary Medicine, Cambridge, UK.
FAU - Duffus, W P
AU  - Duffus WP
FAU - Field, H J
AU  - Field HJ
FAU - Gray, D A
AU  - Gray DA
FAU - Awan, A R
AU  - Awan AR
FAU - O'Brien, M A
AU  - O'Brien MA
FAU - Lunn, D P
AU  - Lunn DP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Equine Vet J
JT  - Equine veterinary journal
JID - 0173320
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Electrolytes)
SB  - IM
CIN - Equine Vet J. 1991 Mar;23(2):78-80. PMID: 2044513
MH  - Animals
MH  - Animals, Newborn/*immunology
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Antibodies, Viral/blood
MH  - Cattle
MH  - Colostrum/chemistry/*immunology
MH  - Electrolytes/analysis
MH  - Female
MH  - Herpesviridae/immunology
MH  - Herpesviridae Infections/immunology/veterinary
MH  - Herpesvirus 1, Equid/immunology
MH  - Horse Diseases/immunology
MH  - Horses/*immunology
MH  - *Immunity, Maternally-Acquired
MH  - Pregnancy
MH  - Specific Pathogen-Free Organisms/*immunology
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 10.1111/j.2042-3306.1991.tb02733.x [doi]
PST - ppublish
SO  - Equine Vet J. 1991 Mar;23(2):111-5. doi: 10.1111/j.2042-3306.1991.tb02733.x.