PMID- 1646158
OWN - NLM
STAT- MEDLINE
DCOM- 19910718
LR  - 20190902
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 10
IP  - 1
DP  - 1991 May
TI  - The human connexin gene family of gap junction proteins: distinct chromosomal 
      locations but similar structures.
PG  - 250-6
AB  - Connexins are protein subunits that constitute gap junction channels. Two members 
      of this gene family, connexin43 (Cx43) and connexin32 (Cx32), are abundantly 
      expressed in the heart and liver, respectively. Human genomic DNA analysis 
      revealed the presence of two loci for Cx43: an expressed gene and a processed 
      pseudogene. The expressed gene (GJA1) was mapped to human chromosome 6 and the 
      pseudogene (GJA1P) to chromosome 5. To determine whether Cx32 was linked to Cx43, 
      somatic cell hybrids were analyzed by polymerase chain reaction and 
      hybridization, resulting in the assignment of the gene for Cx32 (GJB1) to the X 
      chromosome at Xp11----q22. Comparison of the structures of connexin genes 
      suggests that members of this multigene family arose from a single precursor, but 
      evolved to distinct chromosomal locations.
FAU - Fishman, G I
AU  - Fishman GI
AD  - Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 
      10461.
FAU - Eddy, R L
AU  - Eddy RL
FAU - Shows, T B
AU  - Shows TB
FAU - Rosenthal, L
AU  - Rosenthal L
FAU - Leinwand, L A
AU  - Leinwand LA
LA  - eng
SI  - GENBANK/M65188
SI  - GENBANK/M65189
SI  - GENBANK/M65276
SI  - GENBANK/M65277
SI  - GENBANK/M65278
SI  - GENBANK/M65279
SI  - GENBANK/M65280
SI  - GENBANK/M65281
SI  - GENBANK/M65282
SI  - GENBANK/M65283
GR  - 1K11HL02391/HL/NHLBI NIH HHS/United States
GR  - HG00333/HG/NHGRI NIH HHS/United States
GR  - HL37412/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Connexins)
RN  - 0 (Membrane Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - GJA1
GS  - GJA1P
GS  - GJB1
MH  - Base Sequence
MH  - Blotting, Southern
MH  - *Chromosomes, Human, Pair 5
MH  - *Chromosomes, Human, Pair 6
MH  - Connexins
MH  - DNA
MH  - Genetic Linkage
MH  - Humans
MH  - Membrane Proteins/*genetics
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Polymerase Chain Reaction
MH  - Pseudogenes
MH  - Restriction Mapping
MH  - *X Chromosome
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
AID - 0888-7543(91)90507-B [pii]
AID - 10.1016/0888-7543(91)90507-b [doi]
PST - ppublish
SO  - Genomics. 1991 May;10(1):250-6. doi: 10.1016/0888-7543(91)90507-b.