PMID- 1646197 OWN - NLM STAT- MEDLINE DCOM- 19910717 LR - 20240324 IS - 0910-5050 (Print) IS - 1876-4673 (Electronic) IS - 0910-5050 (Linking) VI - 82 IP - 4 DP - 1991 Apr TI - Chromosomal insertion and amplification of human papillomavirus 16 DNA sequences in a cell line of argyrophil small cell carcinoma of the uterine cervix. PG - 371-5 AB - The chromosomal location of human papillomavirus (HPV) 16 DNA sequences integrated in a cell line derived from argyrophil small cell carcinoma of the uterine cervix was determined by means of fluorescence in situ hybridization (FISH). The HPV 16 DNA sequences were integrated near a fragile site and the location of the c-myc oncogene at 8q24.1. Amplification of the integrated viral sequences resulted in an abnormally banded region. The amplified HPV 16 DNA sequences were also detected in every interphase nucleus by FISH. FAU - Hori, T AU - Hori T AD - Division of Genetics, National Institute of Radiological Sciences, Chiba. FAU - Ichimura, H AU - Ichimura H FAU - Minamihisamatsu, M AU - Minamihisamatsu M FAU - Takahashi, E AU - Takahashi E FAU - Yamauchi, M AU - Yamauchi M FAU - Hama, Y AU - Hama Y FAU - Kurimura, O AU - Kurimura O FAU - Yamasaki, M AU - Yamasaki M FAU - Kurimura, T AU - Kurimura T LA - eng PT - Journal Article PL - Japan TA - Jpn J Cancer Res JT - Japanese journal of cancer research : Gann JID - 8509412 RN - 0 (DNA Transposable Elements) RN - 0 (DNA, Viral) RN - 0 (Fluorescent Dyes) RN - 3M4G523W1G (Silver) SB - IM GS - c-myc MH - Carcinoma, Small Cell/genetics/microbiology MH - Cell Line MH - Chromosome Banding MH - Chromosome Fragile Sites MH - Chromosome Fragility MH - Chromosomes, Human, Pair 8 MH - DNA Transposable Elements/*genetics MH - DNA, Viral/genetics MH - Female MH - Fluorescent Dyes MH - Gene Amplification/genetics MH - Genes, myc MH - Humans MH - Nucleic Acid Hybridization MH - Papillomaviridae/*genetics MH - Silver MH - Uterine Cervical Neoplasms/*genetics/*microbiology PMC - PMC5918448 EDAT- 1991/04/01 00:00 MHDA- 1991/04/01 00:01 PMCR- 1991/04/01 CRDT- 1991/04/01 00:00 PHST- 1991/04/01 00:00 [pubmed] PHST- 1991/04/01 00:01 [medline] PHST- 1991/04/01 00:00 [entrez] PHST- 1991/04/01 00:00 [pmc-release] AID - CAE371 [pii] AID - 10.1111/j.1349-7006.1991.tb01857.x [doi] PST - ppublish SO - Jpn J Cancer Res. 1991 Apr;82(4):371-5. doi: 10.1111/j.1349-7006.1991.tb01857.x.