PMID- 16463434
OWN - NLM
STAT- MEDLINE
DCOM- 20060711
LR  - 20220311
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 33
IP  - 3
DP  - 2006 Mar
TI  - Increased concentration of proatherogenic inflammatory cytokines in systemic 
      lupus erythematosus: relationship to cardiovascular risk factors.
PG  - 539-45
AB  - OBJECTIVE: . To examine the hypothesis that patients with systemic lupus 
      erythematosus (SLE) have increased concentrations of interleukin-6 (IL-6), IL-8, 
      and monocyte chemoattractant protein-1 (MCP-1) and that these cytokines are 
      associated with coronary risk factors and atherosclerosis. METHODS: Plasma IL-6, 
      MCP-1, and serum IL-8 (pg/ml) concentrations were measured in 74 patients with 
      SLE and in 85 controls. Clinical characteristics, homocysteine, lipids, 
      erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and coronary 
      artery calcification as detected by electron beam computed tomography were 
      measured. RESULTS: IL-6 (13.2 +/- 13.8 pg/ml vs 6.7 +/- 3.2 pg/ml, p < 0.001) and 
      MCP-1 (264.2 +/- 581.8 pg/ml vs 131.0 +/- 63.7 pg/ml, p < 0.001) concentrations 
      were higher in patients with lupus than in controls. IL-8 concentrations did not 
      differ between patients and controls (p = 0.86). In patients, IL-6 concentrations 
      were correlated with CRP (p < 0.001), ESR (p < 0.001), SLE disease activity index 
      (SLEDAI, p = 0.003), and body mass index (BMI, p = 0.003). IL-6 concentrations 
      were inversely correlated with HDL cholesterol (p = 0.01). MCP-1 concentrations 
      were correlated with SLEDAI (p = 0.01), ESR (p = 0.04), and triglycerides (p = 
      0.03). After controlling for age, sex, disease activity, SLICC damage index, 
      smoking status, and systolic blood pressure, IL-6 was associated with coronary 
      calcification (odds ratio, OR = 1.07, p = 0.035). Similar models found no 
      association between MCP-1 or IL-8 with coronary artery calcification. CONCLUSION: 
      Patients with SLE have increased concentrations of IL-6 and MCP-1. These 
      cytokines are associated with increased inflammation, BMI, and adverse lipid 
      profiles. IL-6 is associated with burden of atherosclerosis in SLE.
FAU - Asanuma, Yu
AU  - Asanuma Y
AD  - Department of Medicine, Vanderbilt University School of Medicine, Nashville, 
      Tennessee 37232-6602, USA.
FAU - Chung, Cecilia P
AU  - Chung CP
FAU - Oeser, Annette
AU  - Oeser A
FAU - Shintani, Ayumi
AU  - Shintani A
FAU - Stanley, Eran
AU  - Stanley E
FAU - Raggi, Paolo
AU  - Raggi P
FAU - Stein, C Michael
AU  - Stein CM
LA  - eng
GR  - GM5M01-RR00095/GM/NIGMS NIH HHS/United States
GR  - HL04012/HL/NHLBI NIH HHS/United States
GR  - HL65082/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060201
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Cytokines)
SB  - IM
CIN - J Rheumatol. 2006 Mar;33(3):445-7. PMID: 16511912
CIN - J Rheumatol. 2006 Dec;33(12):2548; author reply 2548-9. PMID: 17143992
MH  - Adult
MH  - Atherosclerosis/blood/*epidemiology/pathology
MH  - Body Mass Index
MH  - Comorbidity
MH  - Cytokines/*blood
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Lupus Erythematosus, Systemic/blood/*epidemiology/pathology
MH  - Male
MH  - Odds Ratio
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2006/02/08 09:00
MHDA- 2006/07/13 09:00
CRDT- 2006/02/08 09:00
PHST- 2006/02/08 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/02/08 09:00 [entrez]
AID - 06/13/024 [pii]
PST - ppublish
SO  - J Rheumatol. 2006 Mar;33(3):539-45. Epub 2006 Feb 1.