PMID- 16464597
OWN - NLM
STAT- MEDLINE
DCOM- 20060808
LR  - 20220316
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 14
IP  - 10
DP  - 2006 May 15
TI  - New sesquiterpene from Vietnamese agarwood and its induction effect on 
      brain-derived neurotrophic factor mRNA expression in vitro.
PG  - 3571-4
AB  - Agarwood, one of the valuable non-timber products in tropical forest, is a 
      fragrant wood, whose ethereal fragrance has been prized in Asia for incense in 
      ceremony, as well as sedatives in traditional medicine. We separated the 70% EtOH 
      extract of Vietnamese agarwood, which showed significant induction effect on 
      brain-derived neurotrophic factor (BDNF) mRNA expression in rat cultured neuronal 
      cells, to isolate a new compound and a 2-(2-phenylethyl)chromone derivative. The 
      new compound was determined to be a spirovetivane-type sesquiterpene, 
      (4R,5R,7R)-1(10)-spirovetiven-11-ol-2-one, by spectroscopic data and showed 
      induction effect of BDNF mRNA.
FAU - Ueda, Jun-ya
AU  - Ueda JY
AD  - Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 
      930-0194, Japan.
FAU - Imamura, Lisa
AU  - Imamura L
FAU - Tezuka, Yasuhiro
AU  - Tezuka Y
FAU - Tran, Quan L
AU  - Tran QL
FAU - Tsuda, Masaaki
AU  - Tsuda M
FAU - Kadota, Shigetoshi
AU  - Kadota S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060207
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (1(10)-spirovetiven-11-ol-2-one)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sesquiterpenes)
RN  - 0 (Spiro Compounds)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cells, Cultured
MH  - Gene Expression Regulation/*drug effects
MH  - Neurons/drug effects/metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sesquiterpenes/chemistry/isolation & purification/*pharmacology
MH  - Spiro Compounds/chemistry/*pharmacology
MH  - Thymelaeaceae/*chemistry
MH  - Vietnam
EDAT- 2006/02/09 09:00
MHDA- 2006/08/09 09:00
CRDT- 2006/02/09 09:00
PHST- 2005/11/30 00:00 [received]
PHST- 2006/01/06 00:00 [revised]
PHST- 2006/01/07 00:00 [accepted]
PHST- 2006/02/09 09:00 [pubmed]
PHST- 2006/08/09 09:00 [medline]
PHST- 2006/02/09 09:00 [entrez]
AID - S0968-0896(06)00049-6 [pii]
AID - 10.1016/j.bmc.2006.01.023 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2006 May 15;14(10):3571-4. doi: 10.1016/j.bmc.2006.01.023. Epub 
      2006 Feb 7.