PMID- 16465311
OWN - NLM
STAT- MEDLINE
DCOM- 20060510
LR  - 20071114
IS  - 1474-905X (Print)
IS  - 1474-905X (Linking)
VI  - 5
IP  - 2
DP  - 2006 Feb
TI  - Neonatal susceptibility to UV induced cutaneous malignant melanoma in a mouse 
      model.
PG  - 254-60
AB  - UV irradiation has multiple effects on skin including erythema, immunosuppression 
      and the induction of keratinocyte-derived skin cancers and cutaneous malignant 
      melanoma (CMM). CMM which arises from damage to the melanocyte, the pigment cell 
      of the skin, is associated in epidemiologic studies with sun-exposure of 
      susceptible populations, especially children. Our experimental studies have 
      supported the concept that the epidemiologically observed susceptibility in 
      children has a biologic basis. Hepatocyte growth factor/scatter factor (HGF/SF) 
      transgenic mice neonatally irradiated with UV produce melanomas which 
      recapitulate human disease in histopathology and molecular pathogenesis. In this 
      model, neonatal UV is necessary and sufficient for melanoma induction although an 
      additional adult dose of UV radiation significantly increased melanoma 
      multiplicity. One hypothesis for the susceptibility of neonatal mice to induction 
      of melanoma is that neonatal skin contains a large number of immature melanocytes 
      which may result in the retention of the consequences of UV damage throughout the 
      lifetime of the animal. An alternate hypothesis is that the immaturity of the 
      neonatal immune system results in tolerance to melanocytic antigens produced by 
      UV exposure, thus permitting the subsequent outgrowth of melanoma. Here, we 
      discuss the current state of knowledge about the differences between adult and 
      neonatal mice in melanocytes and immune maturation as possible factors playing a 
      role in the susceptibility to melanoma in UV irradiated HGF/SF transgenic mice.
FAU - Wolnicka-Glubisz, Agnieszka
AU  - Wolnicka-Glubisz A
AD  - Department of Environmental and Occupational Health, School of Public Health and 
      Health Services, the George Washington University Medical Center, 2300 Eye 
      Street, NW, Ross Hall, Rm. 110, Washington DC 20037, USA. wolnicka@gwu.edu
FAU - Noonan, Frances P
AU  - Noonan FP
LA  - eng
GR  - CA53765/CA/NCI NIH HHS/United States
GR  - CA92258/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20050727
PL  - England
TA  - Photochem Photobiol Sci
JT  - Photochemical & photobiological sciences : Official journal of the European 
      Photochemistry Association and the European Society for Photobiology
JID - 101124451
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Disease Models, Animal
MH  - Genetic Predisposition to Disease
MH  - Hepatocyte Growth Factor/genetics
MH  - Melanocytes/pathology/*radiation effects
MH  - Melanoma/genetics/immunology/*pathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Neoplasms, Radiation-Induced/genetics/immunology/*pathology
MH  - Skin Neoplasms/genetics/immunology/*pathology
MH  - Ultraviolet Rays/*adverse effects
RF  - 63
EDAT- 2006/02/09 09:00
MHDA- 2006/05/11 09:00
CRDT- 2006/02/09 09:00
PHST- 2006/02/09 09:00 [pubmed]
PHST- 2006/05/11 09:00 [medline]
PHST- 2006/02/09 09:00 [entrez]
AID - 10.1039/b506974b [doi]
PST - ppublish
SO  - Photochem Photobiol Sci. 2006 Feb;5(2):254-60. doi: 10.1039/b506974b. Epub 2005 
      Jul 27.