PMID- 16465524
OWN - NLM
STAT- MEDLINE
DCOM- 20070608
LR  - 20181113
IS  - 0340-2592 (Print)
IS  - 0340-2592 (Linking)
VI  - 45
IP  - 3
DP  - 2006 Mar
TI  - [Cytogenetic alterations in renal tumors. Applications for comparative genomic 
      hybridization and fluorescence in situ hybridization].
PG  - 316-8, 320-2
AB  - The WHO classification of renal cell carcinomas (RCC) takes into account 
      chromosomal alterations. New cytogenetic techniques such as comparative genomic 
      hybridization (CGH) and fluorescence in situ hybridization (FISH) offer 
      alternative methods to the classic cytogenetic banding technique. Clear cell 
      (classic) RCC frequently show the loss of 3p. Papillary RCC are characterized by 
      trisomies and tetrasomies as well as loss of the Y chromosome. CGH analysis 
      demonstrates that DNA copy increase is more common in type I papillary RCC 
      compared to type II. Chromophobe RCC are characterized by losses in chromosomes 
      1, 2, 6, 10, 13, 17, and 21. Oncocytomas can be divided into cases with 
      rearrangements in the 11q13 region and those with loss of chromosome 1 and the 
      sex chromosomes. Translocations involving chromosome 3, such as 
      t(3;8)(p14;q24.13) and t(2;3)(q35;q21) have been described in familial clear cell 
      RCC. The most recent class of RCC, seen only in men, is referred to as 
      translocation tumors. These tumors demonstrate a tubulopapillary growth pattern 
      and have a t(X;1)(p11.2;q21.2) translocation. Although not required for most 
      clinical diagnoses, CGH and FISH complement the standard histologic diagnosis of 
      RCC and may provide a definitive diagnosis in a small number of challenging 
      cases.
FAU - Mertz, K D
AU  - Mertz KD
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Tchinda, J
AU  - Tchinda J
FAU - Kufer, R
AU  - Kufer R
FAU - Moller, P
AU  - Moller P
FAU - Rubin, M A
AU  - Rubin MA
FAU - Moch, H
AU  - Moch H
FAU - Perner, S
AU  - Perner S
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Zytogenetische Veranderungen bei Nierentumoren. Einsatzmoglichkeiten von 
      Chromosomen-CGH und Fluoreszenz-in-situ-Hybridisierung.
PL  - Germany
TA  - Urologe A
JT  - Der Urologe. Ausg. A
JID - 1304110
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Carcinoma, Renal Cell/diagnosis/*genetics
MH  - *Chromosome Banding
MH  - DNA Mutational Analysis
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Genetic Markers/*genetics
MH  - Humans
MH  - *Hybridization, Genetic
MH  - *In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/diagnosis/*genetics
MH  - Male
MH  - Prognosis
MH  - Translocation, Genetic/genetics
RF  - 27
EDAT- 2006/02/09 09:00
MHDA- 2007/06/09 09:00
CRDT- 2006/02/09 09:00
PHST- 2006/02/09 09:00 [pubmed]
PHST- 2007/06/09 09:00 [medline]
PHST- 2006/02/09 09:00 [entrez]
AID - 10.1007/s00120-006-1004-z [doi]
PST - ppublish
SO  - Urologe A. 2006 Mar;45(3):316-8, 320-2. doi: 10.1007/s00120-006-1004-z.