PMID- 16466335
OWN - NLM
STAT- MEDLINE
DCOM- 20060614
LR  - 20060209
IS  - 0277-0008 (Print)
IS  - 0277-0008 (Linking)
VI  - 26
IP  - 2
DP  - 2006 Feb
TI  - Possible effect of thyroid function on anticoagulant response to unfractionated 
      heparin.
PG  - 285-8
AB  - Many factors are known to influence the unfractionated heparin (UFH) dosage 
      required to achieve therapeutic anticoagulation, including weight, sex, age, 
      tobacco smoking, and diabetes mellitus. However, no interaction between thyroid 
      function and UFH has been documented. An 83-year-old Caucasian woman had active 
      hyperthyroidism that appeared to significantly increase her dosage requirements 
      for UFH. The patient had atrial fibrillation secondary to the hyperthyroidism. 
      She had no known factors that would increase UFH requirements. A UHF dosage of 
      1400 U/hour was needed to achieve a therapeutic level of anticoagulation 
      (activated partial thromboplastin time 62 sec). After she was treated for 
      hyperthyroidism, her atrial fibrillation resolved and UFH was discontinued. On 
      day 9 of her hospital admission, atrial fibrillation resumed, and the patient's 
      thyroid function began to normalize. Unfractionated heparin was restarted, and 
      this time therapeutic anticoagulation was achieved with only 800 U/hour. This 
      patient's experience suggests a previously undocumented and clinically 
      significant relationship between active hyperthyroidism and altered dosage 
      requirements for UFH. Recognition of this potential interaction may shorten the 
      time required for patients with hyperthyroidism to achieve therapeutic 
      anticoagulation, thereby preventing complications associated with subtherapeutic 
      anticoagulation.
FAU - Badawi, Omar
AU  - Badawi O
AD  - Visicu, Inc., 217 East Redwood Street, Suite 1900, Baltimore, MD 21202, USA. 
      obadawi@visicu.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pharmacotherapy
JT  - Pharmacotherapy
JID - 8111305
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged, 80 and over
MH  - Anticoagulants/*therapeutic use
MH  - Atrial Fibrillation/etiology
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Hyperthyroidism/*blood/complications
MH  - Partial Thromboplastin Time
MH  - Thyroid Function Tests
EDAT- 2006/02/10 09:00
MHDA- 2006/06/15 09:00
CRDT- 2006/02/10 09:00
PHST- 2006/02/10 09:00 [pubmed]
PHST- 2006/06/15 09:00 [medline]
PHST- 2006/02/10 09:00 [entrez]
AID - 10.1592/phco.26.2.285 [doi]
PST - ppublish
SO  - Pharmacotherapy. 2006 Feb;26(2):285-8. doi: 10.1592/phco.26.2.285.