PMID- 16466892
OWN - NLM
STAT- MEDLINE
DCOM- 20060609
LR  - 20131121
IS  - 0732-8893 (Print)
IS  - 0732-8893 (Linking)
VI  - 54
IP  - 4
DP  - 2006 Apr
TI  - Susceptibility studies of piperazinyl-cross-linked fluoroquinolone dimers against 
      test strains of Gram-positive and Gram-negative bacteria.
PG  - 305-10
AB  - Susceptibility testing was used to evaluate potential spectrum of action for 
      piperazinyl-cross-linked fluoroquinolone dimers against test strains of 
      Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Pseudomonas 
      aeruginosa, Mycobacterium tuberculosis, and vancomycin-resistant Enterococcus 
      faecium (VRE) and to evaluate dimers against fluoroquinolone-resistant and 
      fluoroquinolone-susceptible strains of streptococci. Individual dimers displayed 
      equivalent or lowered MIC values compared with parent fluoroquinolone monomers 
      against test strains of S. pneumoniae, S. pyogenes, E. coli, and VRE. Raised MIC 
      values were observed for all dimers in comparison to monomers against test 
      strains of P. aeruginosa and E. coli. In comparison to parent fluoroquinolones, 
      all dimers displayed decreased percent inhibition of growth against M. 
      tuberculosis. Structural requirements for activity of dimers and partial dimers 
      against all organisms, including lower MICs against certain 
      fluoroquinolone-resistant and fluoroquinolone-susceptible strains of 
      streptococci, were consistent with requirements previously observed for dimers 
      against fluoroquinolone-susceptible and fluoroquinolone-resistant strains of S. 
      aureus. In contrast, the 10- to 100-fold lowering of MICs against wild-type and 
      fluoroquinolone-resistant strains of S. aureus previously observed for individual 
      cross-linked dimers was not observed with test strains of the various organisms 
      used here.
FAU - Kerns, Robert J
AU  - Kerns RJ
AD  - Division of Medicinal and Natural Products Chemistry, The University of Iowa, 
      Iowa City, IA 52242-1112, USA. robert-kerns@uiowa.edu
FAU - Rybak, Michael J
AU  - Rybak MJ
FAU - Cheung, Chrissy M
AU  - Cheung CM
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060208
PL  - United States
TA  - Diagn Microbiol Infect Dis
JT  - Diagnostic microbiology and infectious disease
JID - 8305899
RN  - 0 (Fluoroquinolones)
RN  - 5E8K9I0O4U (Ciprofloxacin)
RN  - N0F8P22L1P (Norfloxacin)
SB  - IM
MH  - Ciprofloxacin/*analogs & derivatives
MH  - Dimerization
MH  - Drug Resistance, Bacterial
MH  - Fluoroquinolones/*chemistry/*pharmacology
MH  - Gram-Negative Bacteria/*drug effects
MH  - Gram-Positive Bacteria/*drug effects
MH  - Microbial Sensitivity Tests
MH  - Norfloxacin/*analogs & derivatives
EDAT- 2006/02/10 09:00
MHDA- 2006/06/10 09:00
CRDT- 2006/02/10 09:00
PHST- 2005/08/03 00:00 [received]
PHST- 2005/11/22 00:00 [revised]
PHST- 2005/11/29 00:00 [accepted]
PHST- 2006/02/10 09:00 [pubmed]
PHST- 2006/06/10 09:00 [medline]
PHST- 2006/02/10 09:00 [entrez]
AID - S0732-8893(05)00340-8 [pii]
AID - 10.1016/j.diagmicrobio.2005.11.004 [doi]
PST - ppublish
SO  - Diagn Microbiol Infect Dis. 2006 Apr;54(4):305-10. doi: 
      10.1016/j.diagmicrobio.2005.11.004. Epub 2006 Feb 8.