PMID- 16469120
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20181113
IS  - 1465-542X (Electronic)
IS  - 1465-5411 (Print)
IS  - 1465-5411 (Linking)
VI  - 8
IP  - 1
DP  - 2006
TI  - Dendritic cell defects in patients with cancer: mechanisms and significance.
PG  - 101
AB  - Dendritic cells (DCs) are a complex network of antigen-presenting cells that have 
      an essential role in the modulation of primary immunity. There has been 
      increasing evidence that DCs isolated from patients with malignancy demonstrate 
      functional deficiencies that inhibit the capacity to mount an effective 
      anti-tumor response. In this issue of Breast Cancer Research, Pinzon-Charry and 
      colleagues investigate one of the possible mechanisms by which tumors induce DC 
      dysfunction to evade host immune surveillance. They demonstrate that DCs isolated 
      from the circulation of patients with early-stage breast cancer exhibit increased 
      rates of spontaneous apoptosis. In vitro studies suggest that a soluble factor 
      secreted by breast cancer cells is responsible for this phenomenon. In contrast, 
      ex vivo conditioning of DCs with CD-40 ligand and IL-12 was protective against 
      tumor-induced apoptosis.
FAU - Lenahan, Corrine
AU  - Lenahan C
AD  - Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, 330 
      Brookline Avenue, Boston, MA 02215, USA.
FAU - Avigan, David
AU  - Avigan D
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20060105
PL  - England
TA  - Breast Cancer Res
JT  - Breast cancer research : BCR
JID - 100927353
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
CON - Breast Cancer Res. 2006;8(1):R5. PMID: 16417648
MH  - *Apoptosis
MH  - Breast Neoplasms/*physiopathology/therapy
MH  - Cell Proliferation
MH  - *Dendritic Cells
MH  - Female
MH  - Humans
MH  - Immunotherapy
MH  - Interleukin-12/*physiology
PMC - PMC1413989
EDAT- 2006/02/14 09:00
MHDA- 2006/03/22 09:00
PMCR- 2006/01/05
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
PHST- 2006/01/05 00:00 [pmc-release]
AID - bcr1375 [pii]
AID - 10.1186/bcr1375 [doi]
PST - ppublish
SO  - Breast Cancer Res. 2006;8(1):101. doi: 10.1186/bcr1375. Epub 2006 Jan 5.