PMID- 16469362
OWN - NLM
STAT- MEDLINE
DCOM- 20070307
LR  - 20220311
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 119
IP  - 1
DP  - 2007
TI  - The lack of association between four point mutations in the promoter region of 
      the toll-like 4 receptor gene and myocardial infarction.
PG  - 105-10
AB  - The toll-like receptor 4 gene product (TLR4) has been implicated in the pathogen 
      recognition response mechanism because it plays a central role in the 
      transcriptional activation of the host defense system. Activation of TLR4 
      initiates an intracellular signaling cascade, via the adapter protein MyD88 
      (myeloid differentiation factor 88), which leads to the activation of NF-kappaB 
      transcriptional factor, and ultimately to the induction of a pro-inflammatory 
      response. This inflammatory response has been increasingly associated with 
      atherosclerosis. Recent analyses on two polymorphisms of TLR4, which affect the 
      extracellular domain of the receptor, have been shown to give rise to an 
      attenuated innate immune defense which may contribute to disease susceptibility. 
      We have investigated the significance of four new substitutions found by 
      re-sequencing in the 5'-proximal promoter region of the TLR4 gene in a 
      case-control study of acute myocardial infarction. Our results found no 
      statistically significant association between these genetic variants and MI.
FAU - De Staercke, Christine
AU  - De Staercke C
AD  - Department of Epidemiology, Rollins School of Public Health, Emory University, 
      Atlanta, Georgia, USA.
FAU - Lally, Cathy
AU  - Lally C
FAU - Austin, Harland
AU  - Austin H
FAU - Winston, Carla
AU  - Winston C
FAU - Dowling, Nicole
AU  - Dowling N
FAU - Williams, Byron
AU  - Williams B
FAU - Hooper, W Craig
AU  - Hooper WC
LA  - eng
PT  - Journal Article
DEP - 20060215
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - Myocardial Infarction/*genetics
MH  - NF-kappa B/metabolism
MH  - *Point Mutation
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Signal Transduction
MH  - Toll-Like Receptor 4/*genetics
EDAT- 2006/02/14 09:00
MHDA- 2007/03/08 09:00
CRDT- 2006/02/14 09:00
PHST- 2005/06/06 00:00 [received]
PHST- 2005/11/19 00:00 [revised]
PHST- 2005/12/16 00:00 [accepted]
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2007/03/08 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - S0049-3848(05)00490-1 [pii]
AID - 10.1016/j.thromres.2005.12.010 [doi]
PST - ppublish
SO  - Thromb Res. 2007;119(1):105-10. doi: 10.1016/j.thromres.2005.12.010. Epub 2006 
      Feb 15.