PMID- 16469503
OWN - NLM
STAT- MEDLINE
DCOM- 20090318
LR  - 20060222
IS  - 1044-5323 (Print)
IS  - 1044-5323 (Linking)
VI  - 18
IP  - 2
DP  - 2006 Apr
TI  - The interactions of dendritic cells with antigen-specific, regulatory T cells 
      that suppress autoimmunity.
PG  - 93-102
AB  - Dendritic cells (DCs) are important for several aspects of the development and 
      function of CD4(+) CD25(+) regulatory T cells (Tregs), which are critical for 
      maintaining peripheral tolerance and preventing autoimmunity. In cultures from 
      human thymus, dendritic cells (DCs) conditioned with thymic stromal lymphopoietin 
      (TSLP) mediate the production of Tregs from CD4(+) CD25(-) thymocytes. In 
      cultures from mouse lymphoid organs, CD86-rich DCs induce the proliferation and 
      improved suppressive function of antigen-specific Tregs. DC-expanded, 
      antigen-specific Tregs show greatly enhanced efficacy relative to polyclonal 
      populations in blocking experimental autoimmunity. In several animal models 
      including NOD diabetes, Tregs directed to one autoantigen are able to block 
      autoimmunity induced by multiple antigens from the target organ. Distinct states 
      of DC differentiation or maturation are likely to be important for the emerging 
      roles of DCs in the biology of Tregs, particularly the control of autoimmunity in 
      an antigen-dependent manner.
FAU - Tarbell, Kristin V
AU  - Tarbell KV
AD  - Laboratory of Cellular Physiology and Immunology and the Chris Browne Center for 
      Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, Box 
      176, New York, NY 10021-6399, USA. tarbelk@rockefeller.edu
FAU - Yamazaki, Sayuri
AU  - Yamazaki S
FAU - Steinman, Ralph M
AU  - Steinman RM
LA  - eng
GR  - 1-K01 DK07158/DK/NIDDK NIH HHS/United States
GR  - 5-P01 AI51573/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20060215
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
RN  - 0 (Epitopes, T-Lymphocyte)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology/pathology/*prevention & control
MH  - Cell Communication/*immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - T-Lymphocytes, Regulatory/cytology/*immunology
RF  - 107
EDAT- 2006/02/14 09:00
MHDA- 2009/03/19 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2009/03/19 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - S1044-5323(06)00010-8 [pii]
AID - 10.1016/j.smim.2006.01.009 [doi]
PST - ppublish
SO  - Semin Immunol. 2006 Apr;18(2):93-102. doi: 10.1016/j.smim.2006.01.009. Epub 2006 
      Feb 15.