PMID- 16469931
OWN - NLM
STAT- MEDLINE
DCOM- 20060217
LR  - 20230817
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 311
IP  - 5762
DP  - 2006 Feb 10
TI  - Essential role of BDNF in the mesolimbic dopamine pathway in social defeat 
      stress.
PG  - 864-8
AB  - Mice experiencing repeated aggression develop a long-lasting aversion to social 
      contact, which can be normalized by chronic, but not acute, administration of 
      antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific 
      knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is 
      required for the development of this experience-dependent social aversion. Gene 
      profiling in the nucleus accumbens indicates that local knockdown of BDNF 
      obliterates most of the effects of repeated aggression on gene expression within 
      this circuit, with similar effects being produced by chronic treatment with 
      antidepressant. These results establish an essential role for BDNF in mediating 
      long-term neural and behavioral plasticity in response to aversive social 
      experiences.
FAU - Berton, Olivier
AU  - Berton O
AD  - Department of Psychiatry and Center for Basic Neuroscience, University of Texas 
      Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, 
      USA.
FAU - McClung, Colleen A
AU  - McClung CA
FAU - Dileone, Ralph J
AU  - Dileone RJ
FAU - Krishnan, Vaishnav
AU  - Krishnan V
FAU - Renthal, William
AU  - Renthal W
FAU - Russo, Scott J
AU  - Russo SJ
FAU - Graham, Danielle
AU  - Graham D
FAU - Tsankova, Nadia M
AU  - Tsankova NM
FAU - Bolanos, Carlos A
AU  - Bolanos CA
FAU - Rios, Maribel
AU  - Rios M
FAU - Monteggia, Lisa M
AU  - Monteggia LM
FAU - Self, David W
AU  - Self DW
FAU - Nestler, Eric J
AU  - Nestler EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 01K63SUP8D (Fluoxetine)
RN  - OGG85SX4E4 (Imipramine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
CIN - Science. 2006 Feb 10;311(5762):759. PMID: 16469888
CIN - Science. 2006 Jun 16;312(5780):1598-9; author reply 1598-9. PMID: 16778038
MH  - Aggression
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Depression/physiopathology
MH  - Dominance-Subordination
MH  - Dopamine/*physiology
MH  - Fluoxetine/pharmacology
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/drug effects
MH  - Imipramine/pharmacology
MH  - Limbic System/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons/physiology
MH  - Nucleus Accumbens/*physiology
MH  - Oligonucleotide Array Sequence Analysis
MH  - Proto-Oncogene Proteins c-fos/biosynthesis
MH  - *Social Behavior
MH  - Social Isolation
MH  - *Stress, Psychological
MH  - Ventral Tegmental Area/metabolism
EDAT- 2006/02/14 09:00
MHDA- 2006/02/18 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/02/18 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - 311/5762/864 [pii]
AID - 10.1126/science.1120972 [doi]
PST - ppublish
SO  - Science. 2006 Feb 10;311(5762):864-8. doi: 10.1126/science.1120972.