PMID- 16470326
OWN - NLM
STAT- MEDLINE
DCOM- 20060330
LR  - 20071115
IS  - 0027-2507 (Print)
IS  - 0027-2507 (Linking)
VI  - 73
IP  - 1
DP  - 2006 Jan
TI  - Diagnosis and management of ST elevation myocardial infarction: a review of the 
      recent literature and practice guidelines.
PG  - 469-81
AB  - There is a large volume of literature available to guide the peri-infarct 
      management of ST elevation myocardial infarction (STEMI). Most of this literature 
      focuses on improving the availability and efficacy of reperfusion therapy. The 
      purpose of this article is to review contemporary scientific evidence and 
      guideline recommendations regarding the diagnosis and therapy of STEMI. Studies 
      and epidemiological data were identified using Medline, the Cochrane Database, 
      and an Internet search engine. Medline was searched for landmark and recent 
      publications using the following key words: STEMI, guidelines, epidemiology, 
      reperfusion, fibrinolytics, percutaneous coronary intervention (PCI), facilitated 
      PCI, transfer, delay, clopidogrel, glycoprotein IIb/IIIa, low-molecular-weight 
      heparin (LMWH), beta-blockers, nitrates, and angiotensin-converting enzyme (ACE) 
      inhibitors. The data accessed indicate that urgent reperfusion with either 
      fibrinolytics or percutaneous intervention should be considered for every patient 
      having symptoms of myocardial infarction with ST segment elevation or a bundle 
      branch block. The utility of combined mechanical and pharmacological reperfusion 
      is currently under investigation. Ancillary treatments may utilize clopidogrel, 
      glycoprotein IIb/IIIa inhibitors, or low molecular weight heparin, depending on 
      the primary reperfusion strategy used. Comprehensive clinical practice guidelines 
      incorporate much of the available contemporary evidence, and are important 
      resources for the evidence-based management of STEMI.
FAU - Hahn, Sigrid A
AU  - Hahn SA
AD  - Department of Emergency Medicine, Box 1149, Mount Sinai School of Medicine, One 
      East 100th Street, New York, NY 10029, USA. Sigrid.Hahn@mssm.edu
FAU - Chandler, Charles
AU  - Chandler C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mt Sinai J Med
JT  - The Mount Sinai journal of medicine, New York
JID - 0241032
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Bundle-Branch Block/diagnosis/therapy
MH  - Electrocardiography
MH  - Fibrinolysis
MH  - Fibrinolytic Agents/therapeutic use
MH  - Humans
MH  - Myocardial Infarction/*diagnosis/drug therapy/*therapy
MH  - Myocardial Reperfusion/adverse effects/*methods
MH  - Platelet Aggregation Inhibitors/therapeutic use
MH  - *Practice Guidelines as Topic
RF  - 68
EDAT- 2006/02/14 09:00
MHDA- 2006/03/31 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/03/31 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
PST - ppublish
SO  - Mt Sinai J Med. 2006 Jan;73(1):469-81.