PMID- 16471212
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20060213
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 26
IP  - 9
DP  - 2005 Sep
TI  - [A case-control study on the association between genetic polymorphisms of 
      metabolic enzymes and the risk of colorectal cancer].
PG  - 659-64
AB  - OBJECTIVE: To investigate the association between metabolic enzymes polymorphisms 
      and the risk of colorectal cancer(CRC). METHODS: Methods of detection used were 
      based on polymerase chain reaction(PCR) including PCR-restriction fragment length 
      polymorphism (PCR-RFLP), allele specific-PCR (AS-PCR) and multiple-PCR to 
      identify the polymorphisms of CYP1A1 6235T/C, CYP1A2 734C/A, CYP2E1 -1259G/C, 
      CYP2E1 -1019C/T, GSTM1 and T1 null type, NAT1 and NAT2 alleles among 140 cases 
      and 343 cancer-free controls. RESULTS: The allele frequencies of CYP1A1 6235C, 
      CYP1A2 734A, CYP2E1 -1259C, CYP2E1 -1019T, GSTM1 and T1 null type, NAT1* 10 and 
      NAT2 Mx (x = 1,2,3) alleles were 31.65%, 63.77%, 23.02%, 32.61%, 57.25%, 17.39%, 
      26.45% and 39.21% in the case group and 39.85%, 66.62%, 20.27%, 28.61%, 55.46%, 
      20.35%, 25.22% and 39.36% in control group, respectively. The frequencies were in 
      Hardy-Weinberg equilibrium. Data on single genetic polymorphism and 
      stratification analysis of multi-genetic polymorphisms indicated that CYP1A1 
      6235CC homozygote was associated with the significant reduction of CRC risk (OR = 
      0.79, 95% CI: 0.63-0.99) and in individuals with CYP1A2 734A allele. CYP1A1 
      62345C allele had the same effect (OR = 0.53, 95% CI: 0.34-0.83). However, 
      individuals with GSTT1 null genotype, GSTM1 null genotype could significantly 
      increase the risk (OR = 4.41, 95% CI: 1.21-16.10). CONCLUSION: CYP1A1 6235C 
      allele might play an important role in fighting against colorectal 
      carcinogenesis. However, GSTM1 and T1 null genotype might serve as risk factors 
      genetically. Larger scale population-based studies were needed to confirm the 
      current findings.
FAU - Chen, Kun
AU  - Chen K
AD  - Departent of Epidemiology and Health Statistics, Zhejiang University School of 
      Public Health, Hangzhou 310031, China.
FAU - Jin, Ming-juan
AU  - Jin MJ
FAU - Fan, Chun-hong
AU  - Fan CH
FAU - Song, Liang
AU  - Song L
FAU - Jiang, Qin-ting
AU  - Jiang QT
FAU - Yu, Wei-ping
AU  - Yu WP
FAU - Ma, Xin-yuan
AU  - Ma XY
FAU - Yao, Kai-yan
AU  - Yao KY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Colorectal Neoplasms/*enzymology/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
EDAT- 2006/02/14 09:00
MHDA- 2010/05/21 06:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Sep;26(9):659-64.