PMID- 16471327
OWN - NLM
STAT- MEDLINE
DCOM- 20060601
LR  - 20061115
IS  - 0392-9078 (Print)
IS  - 0392-9078 (Linking)
VI  - 24
IP  - 4
DP  - 2005 Dec
TI  - C-erb-2 gene amplification and chromosomal anomalies in bladder cancer: 
      preliminary results.
PG  - 633-8
AB  - Studies recently suggested that different genetic factors are involved in the 
      development and progression of bladder cancer. In this study, 30 consecutive 
      patients affected by bladder neoplasm were evaluated in order to analyze the 
      frequency of c-erb-2 gene amplification and chromosome 7, 9, 17 aneusomy using 
      fluorescence in situ hybridization (FISH) technique. C-erb-2 gene amplification, 
      chromosome 17 gain and aneusomy were respectively observed in 3.7% (1/27), in 47% 
      (12/27) and in 74% (20/27) of examined tumors. Moreover, chromosome 7 and 9 
      aneusomy were detected in 74% (20/27) and in 72% (16/27) of specimens. A 
      statistically significant correlation was observed between chromosome 17 aneusomy 
      and tumor stage and grade (r: 0.642, p = 0.0001; r: 0.385, p = 0.04, 
      respectively). In conclusion, we observed a low incidence of C-erb-2 gene 
      amplification, while chromosome 17 aneusomy was confirmed as a marker of advanced 
      and aggressive bladder cancer.
FAU - Leonardo, C
AU  - Leonardo C
AD  - Dept. of Urology, "Parodi Delfino" Hospital, Colleferro, Rome, Italy. 
      costaleo@libero.it
FAU - Merola, R
AU  - Merola R
FAU - Orlandi, G
AU  - Orlandi G
FAU - Leonardo, F
AU  - Leonardo F
FAU - Rondoni, M
AU  - Rondoni M
FAU - De Nunzio, C
AU  - De Nunzio C
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Exp Clin Cancer Res
JT  - Journal of experimental & clinical cancer research : CR
JID - 8308647
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/*genetics/pathology
MH  - *Chromosome Aberrations
MH  - *Gene Amplification
MH  - *Genes, erbB-2
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Urinary Bladder Neoplasms/*genetics/pathology
EDAT- 2006/02/14 09:00
MHDA- 2006/06/02 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/06/02 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
PST - ppublish
SO  - J Exp Clin Cancer Res. 2005 Dec;24(4):633-8.