PMID- 16471461
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20190827
IS  - 0385-2407 (Print)
IS  - 0385-2407 (Linking)
VI  - 32
IP  - 12
DP  - 2005 Dec
TI  - Drug-induced hypersensitivity syndrome associated with human herpesvirus 6 and 
      cytomegalovirus reactivation.
PG  - 976-81
AB  - We describe a patient with drug-induced hypersensitivity syndrome (DIHS) 
      associated with human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) infection 
      induced by sulfasalazine. Two weeks after starting sulfasalazine to treat a 
      rectal ulcer, the patient developed disseminated macular erythema accompanied by 
      fever, liver injury, and lymphadenopathy. Seroconversion of antibodies to HHV-6 
      was observed. Systemic steroid treatment was not effective against the eruptions. 
      Five months after the onset, he presented with an acute febrile disease. The 
      detection of CMV antigen on peripheral blood leukocytes and positive staining for 
      CMV on cutaneous endothelium indicated active CMV infection. Furthermore, he 
      developed a bacteremia of methicillin resistant Staphylococcus aureus. An 
      association the CMV reactivation with DIHS was suggested, although there remains 
      the possibility that the systemic steroid treatment precipitated CMV 
      reactivation. Recently, HHV-6 has been documented to have immunomodulating 
      effects and to be associated with CMV reactivation. Therefore, we should pay 
      attention to the possibility of CMV reactivation in patients with DIHS in whom 
      the immunomodulating virus of HHV-6 has been reactivated.
FAU - Komura, Kazuhiro
AU  - Komura K
AD  - Department of Dermatology, Kanazawa University Graduate School of Medical 
      Science, Kanazawa, Japan.
FAU - Hasegawa, Minoru
AU  - Hasegawa M
FAU - Hamaguchi, Yasuhito
AU  - Hamaguchi Y
FAU - Yukami, Toru
AU  - Yukami T
FAU - Nagai, Masaki
AU  - Nagai M
FAU - Yachie, Akihiro
AU  - Yachie A
FAU - Sato, Shinichi
AU  - Sato S
FAU - Takehara, Kazuhiko
AU  - Takehara K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 3XC8GUZ6CB (Sulfasalazine)
SB  - IM
MH  - Aged
MH  - Cytomegalovirus/physiology
MH  - Cytomegalovirus Infections/*diagnosis/pathology
MH  - Drug Hypersensitivity/*etiology/pathology
MH  - Exanthema Subitum/*chemically induced/pathology
MH  - Facial Dermatoses/chemically induced/pathology
MH  - Follow-Up Studies
MH  - Herpesvirus 6, Human/physiology
MH  - Humans
MH  - Male
MH  - Patch Tests
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sulfasalazine/*adverse effects/therapeutic use
MH  - Syndrome
MH  - *Virus Activation
EDAT- 2006/02/14 09:00
MHDA- 2006/04/14 09:00
CRDT- 2006/02/14 09:00
PHST- 2005/05/11 00:00 [received]
PHST- 2005/06/28 00:00 [accepted]
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - 032120976 [pii]
AID - 10.1111/j.1346-8138.2005.tb00885.x [doi]
PST - ppublish
SO  - J Dermatol. 2005 Dec;32(12):976-81. doi: 10.1111/j.1346-8138.2005.tb00885.x.