PMID- 16472433
OWN - NLM
STAT- MEDLINE
DCOM- 20060215
LR  - 20061115
IS  - 1603-6824 (Electronic)
IS  - 0041-5782 (Linking)
VI  - 168
IP  - 5
DP  - 2006 Jan 30
TI  - [Non-classical human leukocyte antigen (HLA) tissue types--from implantation to 
      transplantation].
PG  - 461-6
AB  - The classical and extremely polymorphic human leukocyte antigens (HLA) classes Ia 
      and II have been studied in great detail and have significant importance in organ 
      transplantation, autoimmune diseases and presentation of antigen peptides. 
      However, in the human major histocompatibility complex (MHC), other functional 
      HLA genes have been detected, the so-called non-classical HLA class Ib genes: 
      HLA-E, -G and -F. They resemble the HLA class Ia antigens in many ways, but 
      several major differences have been described. They are almost monomorphic and 
      generally have a restricted pattern of expression. One function of HLA-E is to 
      inhibit and modulate natural killer (NK) activity. HLA-G seems to be important in 
      the modulation of the maternal immune system during pregnancy and thereby the 
      maternal acceptance of the semi-allogenic foetus. HLA-G can already be detected 
      in at least some blastocysts and probably has a role in implantation. A very 
      strong expression of HLA-G is observed in the invasive trophoblast cells in the 
      placenta. HLA-G may be involved in certain complications of pregnancy and the 
      genetic predisposition to these. Finally, HLA-G expression has been associated 
      with a reduced risk of rejection episodes in heart and kidney/liver transplants.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TV
AD  - Roskilde Amts Sygehus Roskilde, og Hillerod Sygehus, Klinisk Biokemisk Afdeling. 
      hviid@dadlnet.dk
LA  - dan
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - De nonklassiske humant leukocyt-antigen (HLA)-vaevstyper--fra implantation til 
      transplantation.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Autoimmune Diseases/immunology
MH  - Embryo Implantation/*immunology
MH  - Female
MH  - Gene Expression
MH  - Graft Rejection/*immunology
MH  - HLA Antigens/*genetics/physiology
MH  - Histocompatibility Antigens Class I/*genetics/immunology/metabolism
MH  - Histocompatibility Antigens Class II/*genetics/immunology/metabolism
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Polymorphism, Genetic
MH  - Pregnancy
MH  - Pregnancy Complications/immunology
MH  - Transplantation Immunology
MH  - Trophoblasts/immunology
RF  - 40
EDAT- 2006/02/14 09:00
MHDA- 2006/02/16 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/02/16 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - VP46274 [pii]
PST - ppublish
SO  - Ugeskr Laeger. 2006 Jan 30;168(5):461-6.