PMID- 16473024
OWN - NLM
STAT- MEDLINE
DCOM- 20060814
LR  - 20220409
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 31
IP  - 2
DP  - 2006 Jun
TI  - Changes in hippocampal connectivity in the early stages of Alzheimer's disease: 
      evidence from resting state fMRI.
PG  - 496-504
AB  - A selective distribution of Alzheimer's disease (AD) pathological lesions in 
      specific cortical layers isolates the hippocampus from the rest of the brain. 
      However, functional connectivity between the hippocampus and other brain regions 
      remains unclear in AD. Here, we employ a resting state functional MRI (fMRI) to 
      examine changes in hippocampal connectivity comparing 13 patients with mild AD 
      versus 13 healthy age-matched controls. Hippocampal connectivity was investigated 
      by examination of the correlation between low frequency fMRI signal fluctuations 
      in the hippocampus and those in all other brain regions. We found that functional 
      connectivity between the right hippocampus and a set of regions was disrupted in 
      AD; these regions are: medial prefrontal cortex (MPFC), ventral anterior 
      cingulate cortex (vACC), right inferotemporal cortex, right cuneus extending into 
      precuneus, left cuneus, right superior and middle temporal gyrus and posterior 
      cingulate cortex (PCC). We also found increased functional connectivity between 
      the left hippocampus and the right lateral prefrontal cortex in AD. In addition, 
      rightward asymmetry of hippocampal connectivity observed in elderly controls was 
      diminished in AD patients. The disrupted hippocampal connectivity to the MPFC, 
      vACC and PCC provides further support for decreased activity in "default mode 
      network" previously shown in AD. The decreased connectivity between the 
      hippocampus and the visual cortices might indicate reduced integrity of 
      hippocampus-related cortical networks in AD. Moreover, these findings suggest 
      that resting-state fMRI might be an appropriate approach for studying 
      pathophysiological changes in early AD.
FAU - Wang, Liang
AU  - Wang L
AD  - Department of Radiology, Xuanwu Hospital of Capital University of Medical 
      Sciences, Beijing 100053, PR China.
FAU - Zang, Yufeng
AU  - Zang Y
FAU - He, Yong
AU  - He Y
FAU - Liang, Meng
AU  - Liang M
FAU - Zhang, Xinqing
AU  - Zhang X
FAU - Tian, Lixia
AU  - Tian L
FAU - Wu, Tao
AU  - Wu T
FAU - Jiang, Tianzi
AU  - Jiang T
FAU - Li, Kuncheng
AU  - Li K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060209
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*pathology
MH  - Female
MH  - Functional Laterality
MH  - Hippocampus/*anatomy & histology/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Reference Values
EDAT- 2006/02/14 09:00
MHDA- 2006/08/15 09:00
CRDT- 2006/02/14 09:00
PHST- 2005/07/10 00:00 [received]
PHST- 2005/12/14 00:00 [revised]
PHST- 2005/12/20 00:00 [accepted]
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/08/15 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - S1053-8119(05)02571-1 [pii]
AID - 10.1016/j.neuroimage.2005.12.033 [doi]
PST - ppublish
SO  - Neuroimage. 2006 Jun;31(2):496-504. doi: 10.1016/j.neuroimage.2005.12.033. Epub 
      2006 Feb 9.