PMID- 16473308
OWN - NLM
STAT- MEDLINE
DCOM- 20060426
LR  - 20080528
IS  - 1769-7212 (Print)
IS  - 1769-7212 (Linking)
VI  - 49
IP  - 1
DP  - 2006 Jan-Feb
TI  - HLA non-class II genes may confer type I diabetes susceptibility in a Mapuche 
      (Amerindian) affected family.
PG  - 37-41
AB  - A rare case of type I diabetes is studied in an Amerindian (Mapuche) family from 
      Chile, analyzing glutamic acid decarboxylase, islet-cell autoantibodies and human 
      leukocyte antigen (HLA) genes. The affected sib is the only one that has one 
      specific HLA haplotype combination that differs from the other sibs only in the 
      HLA class I genes. It is concluded that HLA diabetes susceptibility factors may 
      be placed outside the class II region or even that susceptibility factors do not 
      exist in the HLA region in this Amerindian family.
FAU - Perez-Bravo, Francisco
AU  - Perez-Bravo F
AD  - Genetic Epidemiology Laboratory, INTA-University of Chile, Santiago, Chile.
FAU - Martinez-Laso, Jorge
AU  - Martinez-Laso J
FAU - Martin-Villa, Jose M
AU  - Martin-Villa JM
FAU - Moscoso, Juan
AU  - Moscoso J
FAU - Moreno, Almudena
AU  - Moreno A
FAU - Serrano-Vela, Juan I
AU  - Serrano-Vela JI
FAU - Zamora, Jorge
AU  - Zamora J
FAU - Asenjo, Silvia
AU  - Asenjo S
FAU - Gleisner, Andrea
AU  - Gleisner A
FAU - Arnaiz-Villena, Antonio
AU  - Arnaiz-Villena A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050217
PL  - Netherlands
TA  - Eur J Med Genet
JT  - European journal of medical genetics
JID - 101247089
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Child
MH  - Diabetes Mellitus, Type 1/ethnology/etiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - *Indians, South American
MH  - Linkage Disequilibrium
MH  - Male
MH  - Pedigree
MH  - Siblings
EDAT- 2006/02/14 09:00
MHDA- 2006/04/28 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - S1769-7212(05)00033-9 [pii]
AID - 10.1016/j.ejmg.2005.01.027 [doi]
PST - ppublish
SO  - Eur J Med Genet. 2006 Jan-Feb;49(1):37-41. doi: 10.1016/j.ejmg.2005.01.027. Epub 
      2005 Feb 17.