PMID- 16473337
OWN - NLM
STAT- MEDLINE
DCOM- 20060725
LR  - 20161124
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1076
IP  - 1
DP  - 2006 Mar 3
TI  - Neurotrophic factors in the central nucleus of amygdala may be organized to 
      provide substrates for associative learning.
PG  - 78-86
AB  - The central nucleus of amygdala was examined to identify the ultrastructural 
      distribution of neurotrophins responsible for the complex of neuronal signaling 
      processes which regulate synaptic transmission and neuronal plasticity, and 
      possibly underlie memory formation. We investigated at the electron microscopic 
      level the cellular organization of brain-derived neurotrophic factor (BDNF) and 
      its receptor, tyrosine kinase receptor B (TrkB), in the extended amygdala (CE). 
      We also investigated the interaction between cortical inputs to CE and BDNF and 
      TrkB. Our results indicate the presence of pro-BDNF and BDNF in terminals in the 
      CE which show a strong association with immunoreactive postsynaptic densities. 
      TrkB receptor immunoreactivity was localized to postsynaptic densities of 
      asymmetric synapses on dendrites and dendritic spines. Cortical terminals formed 
      asymmetric synapses with dendritic shafts and spines, but were not BDNF 
      immunoreactive. TrkB receptors were observed opposed to cortical terminals. These 
      data also suggest that one potential substrate for associative learning may be 
      the interaction of different cortical inputs with neurotrophin-containing 
      terminals ending on dendritic spines and other neuronal structures of CE.
FAU - Agassandian, Khristofor
AU  - Agassandian K
AD  - Department of Anatomy and Cell Biology, The University of Iowa, 51, Newton Road, 
      BSB, Iowa City, IA 52245, USA. khristofor-agassandian@uiowa.edu
FAU - Gedney, Matthew
AU  - Gedney M
FAU - Cassell, Martin D
AU  - Cassell MD
LA  - eng
GR  - MH065452/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060213
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dextrans)
RN  - 0 (biotinylated dextran amine)
RN  - 6SO6U10H04 (Biotin)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Amygdala/metabolism/*physiology/ultrastructure
MH  - Animals
MH  - Association Learning/*physiology
MH  - Behavior, Animal
MH  - Biotin/analogs & derivatives/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dextrans/metabolism
MH  - Diagnostic Imaging/methods
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Microscopy, Immunoelectron/methods
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/metabolism/ultrastructure
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
EDAT- 2006/02/14 09:00
MHDA- 2006/07/26 09:00
CRDT- 2006/02/14 09:00
PHST- 2005/09/16 00:00 [received]
PHST- 2005/12/29 00:00 [revised]
PHST- 2006/01/06 00:00 [accepted]
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/07/26 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - S0006-8993(06)00071-0 [pii]
AID - 10.1016/j.brainres.2006.01.009 [doi]
PST - ppublish
SO  - Brain Res. 2006 Mar 3;1076(1):78-86. doi: 10.1016/j.brainres.2006.01.009. Epub 
      2006 Feb 13.