PMID- 16474202
OWN - NLM
STAT- MEDLINE
DCOM- 20060420
LR  - 20190911
IS  - 1347-8613 (Print)
IS  - 1347-8613 (Linking)
VI  - 100
IP  - 2
DP  - 2006 Feb
TI  - Induction of heme oxygenase-1 inhibits monocyte chemoattractant protein-1 mRNA 
      expression in U937 cells.
PG  - 162-6
AB  - Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential 
      cytoprotective effects. Monocyte activation/migration mediated by monocyte 
      chemoattractant protein-1 (MCP-1) is one of the earliest and important events in 
      the pathogenesis of atherosclerosis. We examined the effect of HO-1 on the 
      production of lysophosphatidylcholine (Lyso-PC)-induced MCP-1 in the human 
      promonocytic cell line U937. Increased HO-1 induction by hemin resulted in a 
      significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. 
      SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the 
      hemin-mediated attenuation of MCP-1 mRNA expression. These results suggest that 
      HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 
      production.
FAU - Shokawa, Tomoki
AU  - Shokawa T
AD  - Department of Molecular and Internal Medicine, Graduate School of Biomedical 
      Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Yoshizumi, Masao
AU  - Yoshizumi M
FAU - Yamamoto, Hideya
AU  - Yamamoto H
FAU - Omura, Shinji
AU  - Omura S
FAU - Toyofuku, Mamoru
AU  - Toyofuku M
FAU - Shimizu, Yoshito
AU  - Shimizu Y
FAU - Imazu, Michinori
AU  - Imazu M
FAU - Kohno, Nobuoki
AU  - Kohno N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060211
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lysophosphatidylcholines)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Ribosomal, 18S)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Chemokine CCL2/*antagonists & inhibitors/genetics
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Induction
MH  - Gene Expression Regulation/*drug effects
MH  - Heme Oxygenase-1/*biosynthesis/genetics
MH  - Humans
MH  - Lysophosphatidylcholines/*pharmacology
MH  - Monocytes/cytology/*drug effects
MH  - RNA, Messenger/*metabolism
MH  - RNA, Ribosomal, 18S/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Time Factors
MH  - U937 Cells
EDAT- 2006/02/14 09:00
MHDA- 2006/04/21 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/04/21 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - JST.JSTAGE/jphs/SC0040188 [pii]
AID - 10.1254/jphs.sc0040188 [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2006 Feb;100(2):162-6. doi: 10.1254/jphs.sc0040188. Epub 2006 
      Feb 11.