PMID- 16475044
OWN - NLM
STAT- MEDLINE
DCOM- 20060607
LR  - 20181113
IS  - 0929-5305 (Print)
IS  - 0929-5305 (Linking)
VI  - 21
IP  - 1
DP  - 2006 Feb
TI  - Anticoagulants in pregnancy.
PG  - 57-65
AB  - Venous thromboembolic (VTE) complications are a leading cause of maternal 
      mortality in the developed world. To reduce the incidence of VTE in pregnancy, 
      and improve outcomes, a wider understanding of the risk factors involved and a 
      better identification of women at risk of thrombosis coupled with effective 
      thromboprophylaxis and treatment of VTE are required. As coumarin is unsuitable 
      for use in pregnancy because of problems with embryopathy and risk of fetal 
      bleeding, anticoagulation therapy in pregnancy centres on the use of 
      low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH). There is 
      now extensive experience of the safety and efficacy of LMWH in pregnancy. LMWH's, 
      such as enoxaparin and dalteparin, have clinical and practical advantages 
      compared with UFH in terms of improved safety (significantly lower incidence of 
      osteoporosis and heparin induced thrombocytopenia), and patient convenience with 
      once daily dosing for the majority of women. Such therapy is not restricted only 
      to prevention and treatment of VTE but is now being assessed in additional 
      clinical situations such as the prevention of pregnancy complications.
FAU - Greer, Ian A
AU  - Greer IA
AD  - Division of Developmental Medicine, Maternal and Reproductive Medicine, Glasgow 
      Royal Infirmary, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, 
      Scotland, U.K. I.A.Greer@clinmed.gla.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Clinical Trials as Topic
MH  - Female
MH  - Fetal Diseases/chemically induced/etiology/prevention & control
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/mortality/*prevention & control
MH  - Pregnancy Outcome
MH  - Thromboembolism/mortality/*prevention & control
RF  - 77
EDAT- 2006/02/14 09:00
MHDA- 2006/06/08 09:00
CRDT- 2006/02/14 09:00
PHST- 2006/02/14 09:00 [pubmed]
PHST- 2006/06/08 09:00 [medline]
PHST- 2006/02/14 09:00 [entrez]
AID - 10.1007/s11239-006-5578-5 [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 2006 Feb;21(1):57-65. doi: 10.1007/s11239-006-5578-5.