PMID- 16476192
OWN - NLM
STAT- MEDLINE
DCOM- 20060728
LR  - 20220716
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 6
IP  - 1
DP  - 2006 Feb
TI  - Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, 
      IgE, and eosinophilia.
PG  - 32-9
AB  - Atopic dermatitis, allergic rhinitis, and bronchial asthma are allergic immune 
      disorders characterized by a predominance of T helper 2 (Th2) cells, the 
      resulting elevation of allergen-specific immunoglobulin E (IgE), and mast cell- 
      and eosinophil-associated inflammation. The cytokine environment at the site of 
      the initial antigen stimulation determines the direction of helper T-cell 
      differentiation into Th1 or Th2 cells. Therefore, negative regulators of cytokine 
      signaling, suppressors of cytokine signaling (SOCS) proteins, play an important 
      role in Th2-mediated allergic responses through the control of the balance 
      between Th1 and Th2 cells. SOCS3 and SOCS5 are predominantly expressed in Th2 and 
      Th1 cells, respectively, and they reciprocally inhibit the Th1 and Th2 
      differentiation processes. In this article, we discuss the role of SOCS3 and 
      SOCS5 proteins in atopic asthma and allergic conjunctivitis and explore the 
      potential of SOCS proteins as targets for therapeutic strategies in allergic 
      disorders.
FAU - Kubo, Masato
AU  - Kubo M
AD  - Laboratory for Signal Network, RIKEN Research Center for Allergy and Immunology 
      (RCAI), RIKEN Yokohama Institute, Suehiro-cho 1-7-22, Tsurumi, Yokohama, Kanagawa 
      230-0045, Japan. raysolfc@rcai.riken.jp
FAU - Inoue, Hiromasa
AU  - Inoue H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Cytokines)
RN  - 0 (SOCS3 protein, human)
RN  - 0 (SOCS5 protein, human)
RN  - 0 (Suppressor of Cytokine Signaling 3 Protein)
RN  - 0 (Suppressor of Cytokine Signaling Proteins)
SB  - IM
MH  - Animals
MH  - Asthma/immunology
MH  - Cytokines/immunology
MH  - Dermatitis, Atopic/immunology
MH  - Eosinophilia/*immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Mice
MH  - Rhinitis, Allergic, Seasonal/immunology
MH  - Suppressor of Cytokine Signaling 3 Protein
MH  - Suppressor of Cytokine Signaling Proteins/*immunology/metabolism
MH  - Th1 Cells/immunology
MH  - Th2 Cells/*immunology/metabolism
RF  - 50
EDAT- 2006/02/16 09:00
MHDA- 2006/07/29 09:00
CRDT- 2006/02/16 09:00
PHST- 2006/02/16 09:00 [pubmed]
PHST- 2006/07/29 09:00 [medline]
PHST- 2006/02/16 09:00 [entrez]
AID - 10.1007/s11882-006-0007-6 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2006 Feb;6(1):32-9. doi: 10.1007/s11882-006-0007-6.