PMID- 16479072
OWN - NLM
STAT- MEDLINE
DCOM- 20060410
LR  - 20181113
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 21
IP  - 1
DP  - 2006 Feb
TI  - Analysis of the monocyte chemoattractant protein 1 -2518 promoter polymorphism in 
      Korean patients with alopecia areata.
PG  - 90-4
AB  - Monocyte chemoattractant protein-1 (MCP-1) levels are increased in scalp lesions 
      of patients with alopecia areata (AA), suggesting a role in the development of 
      AA. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position 
      -2518 has been found, influencing the level of MCP-1 expression in response to an 
      inflammatory stimulus. We investigated whether the presence of these 
      polymorphisms were associated with AA in Korean population. 145 Korean patients 
      with AA, 246 healthy subjects without clinical evidence of AA were screened for 
      genotype with a PCR-based assay. In the AA patients the frequency of the A and G 
      alleles was 40.3 and 59.7%, respectively and the distribution of the A/A, A/G and 
      G/G genotypes was 19.3, 42.1 and 38.6%, respectively. Amongst the controls the 
      frequency of the A and G alleles was 39.8 and 60.2%, and the distribution of the 
      A/A, A/G, G/G genotypes in the same group was 17.5, 44.7 and 37.8%, respectively. 
      There was no significant difference in the allele frequencies and genotype 
      distributions between the patients and the controls (p=0.889, p=0.848, 
      respectively). Our data indicates that no association exists between the -2518A/G 
      polymorphism of the MCP-1 gene and susceptibility to alopecia areata.
FAU - Hong, Seok-Beom
AU  - Hong SB
AD  - Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Jin, Sheng-Yu
AU  - Jin SY
FAU - Park, Hae-Jeong
AU  - Park HJ
FAU - Jung, Joo-Ho
AU  - Jung JH
FAU - Sim, Woo-Young
AU  - Sim WY
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Alopecia Areata/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
PMC - PMC2733986
EDAT- 2006/02/16 09:00
MHDA- 2006/04/11 09:00
PMCR- 2006/02/01
CRDT- 2006/02/16 09:00
PHST- 2006/02/16 09:00 [pubmed]
PHST- 2006/04/11 09:00 [medline]
PHST- 2006/02/16 09:00 [entrez]
PHST- 2006/02/01 00:00 [pmc-release]
AID - 20060290 [pii]
AID - 10.3346/jkms.2006.21.1.90 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2006 Feb;21(1):90-4. doi: 10.3346/jkms.2006.21.1.90.