PMID- 16480519
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20181113
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 7
DP  - 2006 Feb 16
TI  - Electrocortical effects of MDMA are potentiated by acoustic stimulation in rats.
PG  - 13
AB  - BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is known for its 
      toxicological, psychopathological and abuse potential. Some environmental 
      conditions, e.g. acoustic stimulation typical of the "rave scene" can influence 
      the toxicity of this drug. RESULTS: We investigated the effects of low doses of 
      MDMA in vivo using Wistar rats in the absence of acoustic stimulation (white 
      noise; 95 Db) demonstrating that ecstasy is able to induce a significant 
      activation (reduction of Electrocortical total power) of the telencephalic cortex 
      that spontaneously reverts in the absence of sensorial stimuli, whereas it 
      persists for several days if, in addition to MDMA, the animals are exposed to 
      acoustic stimulation. CONCLUSION: Our data demonstrate that low doses of MDMA are 
      able to reduce electrocortical total power, and that this effect is potentiated 
      by sensorial stimuli commonly present in certain environments, such as rave 
      parties.
FAU - Iannone, Michelangelo
AU  - Iannone M
AD  - Section of Pharmacology, CNR-Institute of Neurological Science, Roccelletta di 
      Borgia, Catanzaro, Italy. m.iannone@isn.cnr.it
FAU - Bulotta, Stefania
AU  - Bulotta S
FAU - Paolino, Donatella
AU  - Paolino D
FAU - Zito, Maria Cristina
AU  - Zito MC
FAU - Gratteri, Santo
AU  - Gratteri S
FAU - Costanzo, Francesco S
AU  - Costanzo FS
FAU - Rotiroti, Domenicantonio
AU  - Rotiroti D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060216
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - *Acoustic Stimulation/methods
MH  - Animals
MH  - Cerebral Cortex/*drug effects/radiation effects
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography/methods
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Spectrum Analysis
MH  - Time Factors
PMC - PMC1386694
EDAT- 2006/02/17 09:00
MHDA- 2006/04/14 09:00
PMCR- 2006/02/16
CRDT- 2006/02/17 09:00
PHST- 2005/07/28 00:00 [received]
PHST- 2006/02/16 00:00 [accepted]
PHST- 2006/02/17 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2006/02/17 09:00 [entrez]
PHST- 2006/02/16 00:00 [pmc-release]
AID - 1471-2202-7-13 [pii]
AID - 10.1186/1471-2202-7-13 [doi]
PST - epublish
SO  - BMC Neurosci. 2006 Feb 16;7:13. doi: 10.1186/1471-2202-7-13.