PMID- 16480584
OWN - NLM
STAT- MEDLINE
DCOM- 20061020
LR  - 20150313
VI  - 25
IP  - 2
DP  - 2006 Feb
TI  - [Expression and significance of GST-Pi and HIF-1alpha in bladder carcinoma].
PG  - 190-3
AB  - BACKGROUND & OBJECTIVE: Multidrug resistance plays an important role in 
      chemotherapy failure of bladder cancer, but its mechanism is unclear. Hypoxia in 
      tumors is generally associated with chemoresistance. However, the correlation of 
      nuclear transcription factor hypoxia-inducible factor-1 (HIF-1) to multidrug 
      resistance transporter glutathione-S-transferase-Pi (GST-Pi) has not been 
      investigated. This study was to explore the expression and significance of GST-Pi 
      and its correlation to HIF-1alpha in bladder carcinoma by tissue microarray. 
      METHODS: A tissue microarray containing 119 cases of bladder carcinoma and 6 
      cases of normal bladder tissue was built up. The expression of GST-Pi and 
      HIF-1alpha was detected by SABC immunohistochemistry. RESULTS: In the 119 cases 
      of bladder carcinoma, the positive rate of HIF-1alpha was 57.9%, the positive 
      rate of GST-Pi was 67.2%. The positive rate of HIF-1alpha in G3 grade bladder 
      carcinoma was 64.6%. Their expression was closely related to pathologic grade, 
      clinical stage, and postoperative relapse after adjuvant chemotherapy (P<0.01). 
      HIF-1alpha expression was positively related to GST-Pi expression (P<0.01). 
      CONCLUSIONS: Overexpression of HIF-1alpha may be related to hypoxia. 
      Co-expression of HIF-1alpha and GST-Pi is a object index for judging 
      differentiation and chemoresistance of bladder cancer.
FAU - Deng, Jian-Hua
AU  - Deng JH
AD  - Department of Urology, The First Affiliated Hospital, Lanzhou University, 
      Lanzhou, Gansu 730000, P. R. China. huazai209@163.com
FAU - Bai, Jin-Liang
AU  - Bai JL
FAU - Ma, Peng-Cheng
AU  - Ma PC
FAU - Zhang, Shi-Sheng
AU  - Zhang SS
FAU - Wan, Jiang-Hou
AU  - Wan JH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Ai Zheng
JT  - Ai zheng = Aizheng = Chinese journal of cancer
JID - 9424852
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - EC 2.5.1.18 (Glutathione S-Transferase pi)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/drug therapy/*metabolism/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glutathione S-Transferase pi/*metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*metabolism
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Rate
MH  - Tissue Array Analysis
MH  - Urinary Bladder Neoplasms/drug therapy/*metabolism/pathology
EDAT- 2006/02/17 09:00
MHDA- 2006/10/21 09:00
CRDT- 2006/02/17 09:00
PHST- 2006/02/17 09:00 [pubmed]
PHST- 2006/10/21 09:00 [medline]
PHST- 2006/02/17 09:00 [entrez]
AID - 1000467X2006020190 [pii]
PST - ppublish
SO  - Ai Zheng. 2006 Feb;25(2):190-3.