PMID- 16480826
OWN - NLM
STAT- MEDLINE
DCOM- 20060602
LR  - 20191210
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 121
IP  - 1-2
DP  - 2006 Mar
TI  - Localization of touch versus heat pain in the human hand: a dissociative effect 
      of temporal parameters on discriminative capacity and decision strategy.
PG  - 6-13
AB  - We studied the influence of temporal parameters on localization of 
      monofilament-evoked touch versus thulium laser-induced and C fiber-mediated pain 
      in human subjects. Stimuli were applied at interstimulus intervals (ISIs) varying 
      from 1 to 9 s to determine discrimination between successive stimulus sites in 
      the palmar skin. Localization threshold was about two times higher for heat pain 
      than touch. The localization threshold for pain, but not touch, decreased with 
      prolongation of the ISI from 1 to 7-9 s, and it remained higher for pain even at 
      the ISI of 9 s. The response time was longer for pain than touch, and it 
      increased with an increase in the ISI, independent of the modality. 
      Discriminative capacity, as assessed by the receiver operating characteristics 
      curve, was markedly better for touch than pain. The discriminative capacity 
      decreased with an increase of the ISI, but only for touch. The results indicate 
      that localization is more accurate for touch than pain. Temporal summation of C 
      fiber-evoked pain contributes to the reduced accuracy of pain localization if the 
      ISI is < or = 3 s. Additionally, temporal factors dissociatively influence the 
      response strategy in the tactile versus pain localization task with the 
      prolongation of the ISI from 1 to 9 s. Due to this strategy change, localization 
      threshold for touch remains constant at prolonged ISIs, in spite of a decrease in 
      discriminative capacity. In a cutaneous localization task, the subject's accuracy 
      and response strategy vary with the modality and temporal parameters of 
      sequential test stimulation.
FAU - Ylioja, Shelley
AU  - Ylioja S
AD  - Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland.
FAU - Carlson, Synnove
AU  - Carlson S
FAU - Raij, Tuukka T
AU  - Raij TT
FAU - Pertovaara, Antti
AU  - Pertovaara A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060209
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
SB  - IM
MH  - Adult
MH  - Angioplasty, Laser
MH  - Discrimination, Psychological/*physiology
MH  - Female
MH  - Hand/*innervation
MH  - Hot Temperature/*adverse effects
MH  - Humans
MH  - Male
MH  - Memory/physiology
MH  - Neural Conduction/physiology/radiation effects
MH  - Pain/*physiopathology
MH  - Pain Measurement/methods
MH  - Pain Threshold/*physiology
MH  - Physical Stimulation
MH  - ROC Curve
MH  - Reaction Time
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Touch/*physiology
EDAT- 2006/02/17 09:00
MHDA- 2006/06/03 09:00
CRDT- 2006/02/17 09:00
PHST- 2005/05/11 00:00 [received]
PHST- 2005/10/25 00:00 [revised]
PHST- 2005/11/21 00:00 [accepted]
PHST- 2006/02/17 09:00 [pubmed]
PHST- 2006/06/03 09:00 [medline]
PHST- 2006/02/17 09:00 [entrez]
AID - S0304-3959(05)00598-1 [pii]
AID - 10.1016/j.pain.2005.11.014 [doi]
PST - ppublish
SO  - Pain. 2006 Mar;121(1-2):6-13. doi: 10.1016/j.pain.2005.11.014. Epub 2006 Feb 9.