PMID- 16483169
OWN - NLM
STAT- MEDLINE
DCOM- 20070410
LR  - 20060217
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 12
IP  - 1
DP  - 2006 Jan
TI  - [Effect of soluble granule of Shengjing on the apoptosis in spermatogenic cells 
      of rats caused by varicocele].
PG  - 83-5
AB  - OBJECTIVE: To investigate the apoptosis of spermatogenic cells of rats caused by 
      experimental varicocele and effect of soluble granules of Shengjing on the 
      apoptosis. METHODS: Sixty Wistar male rats were divided into three group: control 
      group, model group, and treatment group. Experimental varicocele was induced by 
      partial ligation of the left renal vein in Wistar rat. Apoptosis cells in the 
      testes were detected by in situ terminal deoxynucleotidyl transferase-mediated 
      dUTP nick end labeling(TUNEL) Technique. RESULTS: The apoptosis index in model 
      group was remarkably higher than that in control group (P < 0.001). There was 
      significant difference between treatment and model groups in apoptosis index. 
      CONCLUSION: The apoptosis of spermatogenic cells by varicocele may play a 
      important role in leading to subfertility. The soluble granules of Shengjing have 
      negative effects on the apoptosis of spermatogenic cells. The medicine can not 
      only protect spermic production but improve the ability of procreation of testes.
FAU - Zhou, Chuan-ye
AU  - Zhou CY
AD  - Department of Urology, No. 455 Hospital of PLA, Shanghai 200052, China.
FAU - An, Li-wen
AU  - An LW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Infertility, Male/drug therapy/etiology
MH  - Male
MH  - Phytotherapy
MH  - Rats
MH  - Rats, Wistar
MH  - Spermatozoa/drug effects/*pathology
MH  - Varicocele/complications/drug therapy/*pathology
EDAT- 2006/02/18 09:00
MHDA- 2007/04/11 09:00
CRDT- 2006/02/18 09:00
PHST- 2006/02/18 09:00 [pubmed]
PHST- 2007/04/11 09:00 [medline]
PHST- 2006/02/18 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2006 Jan;12(1):83-5.