PMID- 1648334
OWN - NLM
STAT- MEDLINE
DCOM- 19910806
LR  - 20131121
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 11
IP  - 2
DP  - 1991 Mar-Apr
TI  - Cytotoxic effect of the association of BCNU with rhein or lonidamine on a human 
      glioma cell line.
PG  - 789-92
AB  - The effect of association of 1,3-bis-(2-chloroethyl)-l-nitrosourea (BCNU)- Rhein 
      (RH) and BCNU-Lonidamine (LND) on the clonogenic activity of human glioma cells 
      was evaluated. Both RH and LND modulate the lethal effect of BCNU regardless of 
      the schedule of treatment. The analysis of the interactions, performed with the 
      isbolar method according to Berembaum, demonstrates an additivity of the effects. 
      The possible mechanisms as well as the implications for the design of brain tumor 
      schedule treatment are discussed.
FAU - Floridi, A
AU  - Floridi A
AD  - Laboratory for Cell Metabolism and Pharmacokinetics Regina Elena Institute for 
      Cancer Research, Rome, Italy.
FAU - Gentile, P F
AU  - Gentile PF
FAU - Bruno, T
AU  - Bruno T
FAU - Fanciulli, M
AU  - Fanciulli M
FAU - Paggi, M G
AU  - Paggi MG
FAU - Zeuli, M
AU  - Zeuli M
FAU - Benassi, M
AU  - Benassi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Anthraquinones)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Indazoles)
RN  - EC 1.6.- (NADH, NADPH Oxidoreductases)
RN  - U68WG3173Y (Carmustine)
RN  - U78804BIDR (lonidamine)
RN  - YM64C2P6UX (rhein)
SB  - IM
MH  - Anthraquinones/*pharmacology
MH  - Antineoplastic Agents/*pharmacology
MH  - Brain Neoplasms
MH  - Carmustine/*pharmacology
MH  - Cell Line
MH  - Cell Survival/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Glioblastoma
MH  - Humans
MH  - Indazoles/*pharmacology
MH  - Kinetics
MH  - NADH, NADPH Oxidoreductases/*antagonists & inhibitors
MH  - Tumor Stem Cell Assay
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1991 Mar-Apr;11(2):789-92.