PMID- 16484744
OWN - NLM
STAT- MEDLINE
DCOM- 20060710
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 45
IP  - 2
DP  - 2006
TI  - Multiple endocrine neoplasia type I and Cushing's syndrome due to an aggressive 
      ACTH producing thymic carcinoid.
PG  - 81-6
AB  - Thymic carcinoid in multiple endocrine neoplasia type 1 (MEN 1) is previously 
      reported as a non-ACTH producing tumor. The present case is a 39-year-old man 
      with mortal outcome from thymic carcinoid and Cushing's syndrome with high plasma 
      ACTH. The symptom was first observed at age 29 and was relieved after extended 
      thymectomy, with reduction of ACTH level. The tumor was positive for ACTH, 
      Grimelius silver staining and Chromogranin A. The finding of primary 
      hyperparathyroidism, pituitary adenoma, and a novel germline nonsense mutation 
      (W423X) established the diagnosis of MEN 1. Cushing's syndrome due to ACTH 
      producing thymic carcinoid should be also considered as one phenotype of the MEN 
      1 spectrum.
FAU - Takagi, Junko
AU  - Takagi J
AD  - Department of Laboratory Medicine, Aichi Medical University School of Medicine, 
      Nagakute, Aichi.
FAU - Otake, Kazuo
AU  - Otake K
FAU - Morishita, Munehiko
AU  - Morishita M
FAU - Kato, Harumichi
AU  - Kato H
FAU - Nakao, Naoki
AU  - Nakao N
FAU - Yoshikawa, Kazuhiro
AU  - Yoshikawa K
FAU - Ikeda, Hiroshi
AU  - Ikeda H
FAU - Hirooka, Yoshifumi
AU  - Hirooka Y
FAU - Hattori, Yoshinobu
AU  - Hattori Y
FAU - Larsson, Catharina
AU  - Larsson C
FAU - Nogimori, Tsuyoshi
AU  - Nogimori T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20060215
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Antineoplastic Agents, Hormonal)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - ACTH Syndrome, Ectopic/blood/*etiology
MH  - Adrenocorticotropic Hormone/blood
MH  - Adult
MH  - Antineoplastic Agents, Hormonal/therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & dosage
MH  - Carcinoid Tumor/blood/*complications/pathology/therapy
MH  - Combined Modality Therapy
MH  - Cushing Syndrome/blood/*etiology
MH  - Fatal Outcome
MH  - Germ-Line Mutation
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/blood/*diagnosis/genetics/therapy
MH  - Octreotide/therapeutic use
MH  - Radiotherapy, Adjuvant
MH  - Thymectomy
MH  - Thymus Neoplasms/blood/*complications/pathology/therapy
EDAT- 2006/02/18 09:00
MHDA- 2006/07/13 09:00
CRDT- 2006/02/18 09:00
PHST- 2006/02/18 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/02/18 09:00 [entrez]
AID - JST.JSTAGE/internalmedicine/45.1427 [pii]
AID - 10.2169/internalmedicine.45.1427 [doi]
PST - ppublish
SO  - Intern Med. 2006;45(2):81-6. doi: 10.2169/internalmedicine.45.1427. Epub 2006 Feb 
      15.