PMID- 16484775
OWN - NLM
STAT- MEDLINE
DCOM- 20060313
LR  - 20061115
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 112
IP  - 3-4
DP  - 2006
TI  - Different breakage-prone regions on chromosome 1 detected in t(11;14)-positive 
      mantle cell lymphoma cell lines and multiple myeloma cell lines are associated 
      with different tumor progression-related mechanisms.
PG  - 213-21
AB  - To better define secondary aberrations that occur in addition to translocation 
      t(11;14)(q13;q32) in mantle cell lymphomas (MCL) and in multiple myelomas (MM), 
      seven t(11;14)-positive MCL cell lines and four t(11;14)-positive MM cell lines 
      were analysed by fluorescence R-banding and spectral karyotyping (SKY). Compared 
      with published data obtained by G-banding, most chromosome aberrations were 
      redefined or further specified. Furthermore, several additional chromosome 
      aberrations were identified. Thus, these cytogenetically well defined 
      t(11;14)-positive MCL and MM cell lines may be useful tools for the 
      identification and characterization of genes that might be involved in the 
      pathogenesis of MCL and MM, respectively. Since MCL and MM were found to have 
      different alterations of chromosome 1, these were investigated in more detail by 
      fluorescence in situ hybridization (FISH) and multicolor banding (MCB) analyses. 
      The most frequently altered and deletion-prone loci in MCL cell lines were 
      regions 1p31 and 1p21. In contrast, breakpoints in MM cell lines most often 
      involved the heterochromatic regions 1p12-->p11, and the subcentromeric regions 
      1q12 and 1q21. These data are in accordance with previously published data of 
      primary lymphomas. Our findings may indicate that different pathways of clonal 
      evolution are involved in these morphologically distinct lymphomas harboring an 
      identical primary chromosome aberration, t(11;14).
CI  - 2006 S. Karger AG, Basel.
FAU - Rudolph, C
AU  - Rudolph C
AD  - Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, 
      Germany. Rudolph.Cornelia@mh-hannover.de
FAU - Liehr, T
AU  - Liehr T
FAU - Steinemann, D
AU  - Steinemann D
FAU - Emura, M
AU  - Emura M
FAU - Daibata, M
AU  - Daibata M
FAU - Matsuo, Y
AU  - Matsuo Y
FAU - Emi, N
AU  - Emi N
FAU - Abe, M
AU  - Abe M
FAU - Lai, R
AU  - Lai R
FAU - Mrasek, K
AU  - Mrasek K
FAU - Claussen, U
AU  - Claussen U
FAU - Schlegelberger, B
AU  - Schlegelberger B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Cell Line, Tumor
MH  - Chromosome Breakage/*genetics
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 8
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Karyotyping
MH  - Lymph Nodes/pathology
MH  - Lymphoma, Mantle-Cell/*genetics/immunology
MH  - Male
MH  - Multiple Myeloma/*genetics/immunology
MH  - Pleural Effusion/pathology
MH  - *Translocation, Genetic
EDAT- 2006/02/18 09:00
MHDA- 2006/03/15 09:00
CRDT- 2006/02/18 09:00
PHST- 2005/02/28 00:00 [received]
PHST- 2005/07/22 00:00 [accepted]
PHST- 2006/02/18 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2006/02/18 09:00 [entrez]
AID - 89873 [pii]
AID - 10.1159/000089873 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2006;112(3-4):213-21. doi: 10.1159/000089873.