PMID- 16487451
OWN - NLM
STAT- MEDLINE
DCOM- 20070416
LR  - 20161020
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 10
IP  - 2
DP  - 2007 Apr
TI  - 3,4-Methylenedioxymethamphetamine (MDMA), but not morphine, alters APP processing 
      in the rat brain.
PG  - 183-90
AB  - The abuse of drugs such as opioids and 3,4-methylenedioxymethamphetamine (MDMA or 
      'ecstasy') can have detrimental effects on the cognitive functions, but the exact 
      molecular mechanism whereby these drugs promote neurodegeneration remains to be 
      elucidated. The major purpose of the present pilot study was to determine whether 
      the chronic in-vivo administration of morphine (10 mg/kg) or MDMA (1 mg/kg) to 
      rats can alter the expression and processing of amyloid precursor protein (APP), 
      the central molecule in the proposed pathomechanism of Alzheimer's disease. MDMA 
      treatment significantly decreased the production of APP in the cytosolic fraction 
      of the brain cortex. A concomitant 25% increase was found both in the 
      beta-secretase (BACE) and APP mRNA levels (108%). In contrast, in the applied 
      single dosage chronic morphine treatment did not influence either the APP and 
      BACE protein levels or the APP mRNA production. These results indicate that the 
      chronic use of 'ecstasy', but not morphine, may be harmful via a novel mode of 
      action, i.e. by altering the APP expression and processing in the brain.
FAU - Kalman, Janos
AU  - Kalman J
AD  - Department of Psychiatry and Alzheimer's Disease Research Centre, Albert 
      Szent-Gyorgyi Center for Medical and Pharmaceutical Sciences, Faculty of 
      Medicine, University of Szeged, Szeged, Hungary. kalmanj@nepsy.szote.u-szeged.hu
FAU - Bjelik, Annamaria
AU  - Bjelik A
FAU - Hugyecz, Marietta
AU  - Hugyecz M
FAU - Timar, Julia
AU  - Timar J
FAU - Gyarmati, Zsuzsanna
AU  - Gyarmati Z
FAU - Zana, Marianna
AU  - Zana M
FAU - Furst, Zsuzsanna
AU  - Furst Z
FAU - Janka, Zoltan
AU  - Janka Z
FAU - Rakonczay, Zoltan
AU  - Rakonczay Z
FAU - Horvath, Zoltan
AU  - Horvath Z
FAU - Pakaski, Magdolna
AU  - Pakaski M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060217
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Agents)
RN  - 76I7G6D29C (Morphine)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Amyloid beta-Protein Precursor/biosynthesis/*metabolism
MH  - Analgesics, Opioid/*pharmacology
MH  - Animals
MH  - Blotting, Western
MH  - Brain Chemistry/*drug effects
MH  - Densitometry
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Female
MH  - Morphine/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Serotonin Agents/*pharmacology
EDAT- 2006/02/21 09:00
MHDA- 2007/04/17 09:00
CRDT- 2006/02/21 09:00
PHST- 2005/05/05 00:00 [received]
PHST- 2005/12/23 00:00 [revised]
PHST- 2005/12/29 00:00 [accepted]
PHST- 2006/02/21 09:00 [pubmed]
PHST- 2007/04/17 09:00 [medline]
PHST- 2006/02/21 09:00 [entrez]
AID - S146114570600650X [pii]
AID - 10.1017/S146114570600650X [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2007 Apr;10(2):183-90. doi: 
      10.1017/S146114570600650X. Epub 2006 Feb 17.