PMID- 16487598 OWN - NLM STAT- MEDLINE DCOM- 20060831 LR - 20220318 IS - 0165-0327 (Print) IS - 0165-0327 (Linking) VI - 91 IP - 2-3 DP - 2006 Apr TI - Behavioral activation system deficits predict the six-month course of depression. PG - 229-34 AB - BACKGROUND: Behavioral activation system (BAS) deficits are hypothesized to increase risk for depression. This study tested the hypothesis that BAS deficits, measured with both self-report and electrophysiological methods, would predict the six-month course of depression. METHODS: 67 participants with major depressive disorder (MDD) with or without pre-existing dysthymia were assessed at baseline with Carver and White's [Carver, C.S., White, T.L., 1994. Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS scales. J. Pers. Soc. Psychol. 67, 319-333.] BIS/BAS scales and resting EEG. The week-by-week course of their depressive symptoms was assessed six months later with the Longitudinal Interval Follow-up Evaluation (LIFE). RESULTS: Baseline self-reported BAS sensitivity predicted depression diagnosis (MDD or dysthymia) at follow-up, number of MDD symptoms at follow-up, average weekly level of depression, and time to recovery. These effects persisted after controlling for baseline clinical variables associated with a worse course. Baseline resting EEG alpha asymmetry did not significantly predict the course of depression. LIMITATIONS: Although BAS sensitivity predicted the subsequent course of depression, we cannot determine whether it played a causal role in maintaining depression. CONCLUSIONS: Lower self-reported BAS sensitivity predicts a worse course of depression but EEG asymmetries do not. FAU - McFarland, Brian R AU - McFarland BR AD - Psychology Department, Stony Brook University, NY 11794-2500, USA. brian.mcfarland@sunysb.edu FAU - Shankman, Stewart A AU - Shankman SA FAU - Tenke, Craig E AU - Tenke CE FAU - Bruder, Gerard E AU - Bruder GE FAU - Klein, Daniel N AU - Klein DN LA - eng PT - Journal Article DEP - 20060217 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Adolescent MH - Adult MH - Depressive Disorder, Major/*epidemiology MH - Diagnostic and Statistical Manual of Mental Disorders MH - Electroencephalography MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Mental Disorders/*diagnosis/*epidemiology MH - Middle Aged MH - Predictive Value of Tests MH - Prognosis MH - Rest EDAT- 2006/02/21 09:00 MHDA- 2006/09/01 09:00 CRDT- 2006/02/21 09:00 PHST- 2005/10/13 00:00 [received] PHST- 2005/12/23 00:00 [revised] PHST- 2006/01/06 00:00 [accepted] PHST- 2006/02/21 09:00 [pubmed] PHST- 2006/09/01 09:00 [medline] PHST- 2006/02/21 09:00 [entrez] AID - S0165-0327(06)00013-9 [pii] AID - 10.1016/j.jad.2006.01.012 [doi] PST - ppublish SO - J Affect Disord. 2006 Apr;91(2-3):229-34. doi: 10.1016/j.jad.2006.01.012. Epub 2006 Feb 17.