PMID- 16487792
OWN - NLM
STAT- MEDLINE
DCOM- 20060327
LR  - 20171116
IS  - 0074-7696 (Print)
IS  - 0074-7696 (Linking)
VI  - 248
DP  - 2006
TI  - Vomeronasal versus olfactory epithelium: is there a cellular basis for human 
      vomeronasal perception?
PG  - 209-59
AB  - The vomeronasal organ (VNO) constitutes an accessory olfactory organ that 
      receives chemical stimuli, pheromones, which elicit behavioral, reproductive, or 
      neuroendocrine responses among individuals of the same species. In many 
      macrosmatic animals, the morphological substrate constitutes a separate organ 
      system consisting of a vomeronasal duct (ductus vomeronasalis, VND), equipped 
      with chemosensory cells, and a vomeronasal nerve (nervus vomeronasalis, VNN) 
      conducting information into the accessory olfactory bulb (AOB) in the central 
      nervous system (CNS). Recent data require that the long-accepted dual 
      functionality of a main olfactory system and the VNO be reexamined, since all 
      species without a VNO are nevertheless sexually active, and species possessing a 
      VNO also can sense other than "vomeronasal" stimuli via the vomeronasal 
      epithelium (VNE). The human case constitutes a borderline situation, as its 
      embryonic VNO anlage exerts a developmental track common to most macrosmatics, 
      but later typical structures such as the VNN, AOB, and probably most of the 
      chemoreceptor cells within the still existent VND are lost. This review also 
      presents recent information on the VND including immunohistochemical expression 
      of neuronal markers, intermediate filaments, lectins, integrins, caveolin, CD44, 
      and aquaporins. Further, we will address the issue of human pheromone candidates.
FAU - Witt, Martin
AU  - Witt M
AD  - Department of Anatomy, University of Technology Dresden, Dresden, Germany.
FAU - Hummel, Thomas
AU  - Hummel T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Int Rev Cytol
JT  - International review of cytology
JID - 2985180R
RN  - 0 (Aquaporins)
RN  - 0 (Caveolins)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Integrins)
RN  - 0 (Lectins)
RN  - 0 (Pheromones)
SB  - IM
MH  - Animals
MH  - Aquaporins/metabolism
MH  - Caveolins/metabolism
MH  - Humans
MH  - Hyaluronan Receptors/metabolism
MH  - Integrins/metabolism
MH  - Intermediate Filaments/metabolism
MH  - Lectins/metabolism
MH  - Morphogenesis
MH  - *Olfactory Mucosa/cytology/growth & development/physiology
MH  - Pheromones/metabolism
MH  - Smell/*physiology
MH  - *Vomeronasal Organ/anatomy & histology/growth & development/physiology
RF  - 235
EDAT- 2006/02/21 09:00
MHDA- 2006/03/28 09:00
CRDT- 2006/02/21 09:00
PHST- 2006/02/21 09:00 [pubmed]
PHST- 2006/03/28 09:00 [medline]
PHST- 2006/02/21 09:00 [entrez]
AID - S0074-7696(06)48004-9 [pii]
AID - 10.1016/S0074-7696(06)48004-9 [doi]
PST - ppublish
SO  - Int Rev Cytol. 2006;248:209-59. doi: 10.1016/S0074-7696(06)48004-9.