PMID- 16488482
OWN - NLM
STAT- MEDLINE
DCOM- 20060803
LR  - 20171116
IS  - 0165-0378 (Print)
IS  - 0165-0378 (Linking)
VI  - 70
IP  - 1-2
DP  - 2006 Jun
TI  - Expression patterns of lectin-like natural killer receptors, inhibitory 
      CD94/NKG2A, and activating CD94/NKG2C on decidual CD56bright natural killer cells 
      differ from those on peripheral CD56dim natural killer cells.
PG  - 33-42
AB  - The balance of inhibitory and activating natural killer (NK) receptors on 
      maternal decidual NK cells, most of which are CD56bright, is thought to be 
      crucial for the proper growth of trophoblasts in placenta. A lectin-like NK 
      receptor, CD94/NKG2, is the receptor for human leukocyte antigen (HLA)-E, which 
      is expressed on trophoblasts. To clarify the mechanism regulating the activity of 
      decidual NK cells during pregnancy, we investigated the expression patterns of 
      inhibitory NK receptor, CD94/NKG2A, and activating receptor, CD94/NKG2C, on 
      decidual NK cells in an early stage of normal pregnancy and compared them with 
      those on peripheral NK cells, most of which are CD56dim. The rate of 
      NKG2A-positive cells was significantly higher for decidual CD56bright NK cells 
      than for peripheral CD56dim NK cells, but the rates of NKG2C-positive cells were 
      comparable between the two cell types. Interestingly, peripheral CD56dim NK cells 
      reciprocally expressed inhibitory NKG2A and activating NKG2C, but decidual 
      CD56bright NK cells that expressed activating NKG2C simultaneously expressed 
      inhibitory NKG2A. The co-expression of inhibitory and activating NKG2 receptors 
      may fine-tune the immunoregulatory functions of the decidual NK cells to control 
      the trophoblast invasion in constructing placenta.
FAU - Kusumi, Maki
AU  - Kusumi M
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
FAU - Yamashita, Takahiro
AU  - Yamashita T
FAU - Fujii, Tomoyuki
AU  - Fujii T
FAU - Nagamatsu, Takeshi
AU  - Nagamatsu T
FAU - Kozuma, Shiro
AU  - Kozuma S
FAU - Taketani, Yuji
AU  - Taketani Y
LA  - eng
PT  - Journal Article
DEP - 20060220
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (CD56 Antigen)
RN  - 0 (CLEC2D protein, human)
RN  - 0 (KLRC1 protein, human)
RN  - 0 (KLRC2 protein, human)
RN  - 0 (KLRD1 protein, human)
RN  - 0 (Lectins, C-Type)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily C)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily D)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Natural Killer Cell)
SB  - IM
MH  - CD56 Antigen/biosynthesis/*immunology
MH  - Decidua/cytology/immunology
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Lectins, C-Type/immunology
MH  - NK Cell Lectin-Like Receptor Subfamily C
MH  - NK Cell Lectin-Like Receptor Subfamily D/biosynthesis/*immunology
MH  - Pregnancy
MH  - Receptors, Cell Surface/immunology
MH  - Receptors, Immunologic/*biosynthesis/immunology
MH  - Receptors, Natural Killer Cell
MH  - Trophoblasts/cytology/immunology
EDAT- 2006/02/21 09:00
MHDA- 2006/08/04 09:00
CRDT- 2006/02/21 09:00
PHST- 2005/04/28 00:00 [received]
PHST- 2005/11/20 00:00 [revised]
PHST- 2005/12/06 00:00 [accepted]
PHST- 2006/02/21 09:00 [pubmed]
PHST- 2006/08/04 09:00 [medline]
PHST- 2006/02/21 09:00 [entrez]
AID - S0165-0378(06)00003-9 [pii]
AID - 10.1016/j.jri.2005.12.008 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2006 Jun;70(1-2):33-42. doi: 10.1016/j.jri.2005.12.008. Epub 
      2006 Feb 20.