PMID- 16488636
OWN - NLM
STAT- MEDLINE
DCOM- 20060616
LR  - 20081121
IS  - 1095-6433 (Print)
IS  - 1095-6433 (Linking)
VI  - 143
IP  - 4
DP  - 2006 Apr
TI  - Oxidative stress and HIF-1 DNA binding during stressful cold exposure and 
      recovery in the North Sea eelpout (Zoarces viviparus).
PG  - 494-503
AB  - Effects of acute cold exposure (at 1 degrees C and 5 degrees C) on tissue redox 
      state and oxidative stress parameters, as well as the onset of hypoxic signaling 
      were investigated in the North Sea eelpout, Zoarces viviparus. Activation of the 
      transcription factor HIF-1 (hypoxia inducible factor) was detected in liver 
      samples after acute cold exposure. At this temperature the cellular redox milieu 
      was significantly reduced (below -270 mV) as compared to controls (-250 to -267 
      mV). Increased levels of oxidative stress parameters (TBARS and protein 
      carbonyls) were observed mainly during recovery at control temperature (12 
      degrees C). This increase in oxidative stress parameters, in spite of maintained 
      antioxidant capacity, indicates that acute cold stress and recovery mimic 
      ischemia/reperfusion events as found in mammals. Notably the non-enzymatic 
      antioxidant defense (e.g. glutathione) may play an important role for eelpout ROS 
      scavenging capacity under cold stress.
FAU - Heise, Katja
AU  - Heise K
AD  - Alfred-Wegener-Institute for Polar and Marine Research, Physiology of Marine 
      Animals, Am Handelshafen 12, 27570 Bremerhaven, Germany.
FAU - Puntarulo, Susana
AU  - Puntarulo S
FAU - Nikinmaa, Mikko
AU  - Nikinmaa M
FAU - Lucassen, Magnus
AU  - Lucassen M
FAU - Portner, Hans-O
AU  - Portner HO
FAU - Abele, Doris
AU  - Abele D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060220
PL  - United States
TA  - Comp Biochem Physiol A Mol Integr Physiol
JT  - Comparative biochemistry and physiology. Part A, Molecular & integrative 
      physiology
JID - 9806096
RN  - 0 (Antioxidants)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Behavior, Animal
MH  - Cold Temperature
MH  - DNA/*metabolism
MH  - Hypoxia-Inducible Factor 1/genetics/*metabolism
MH  - Liver/metabolism
MH  - North Sea
MH  - *Oxidative Stress
MH  - Perciformes/*physiology
MH  - Signal Transduction
MH  - Stress, Physiological
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2006/02/21 09:00
MHDA- 2006/06/17 09:00
CRDT- 2006/02/21 09:00
PHST- 2005/07/18 00:00 [received]
PHST- 2006/01/09 00:00 [revised]
PHST- 2006/01/10 00:00 [accepted]
PHST- 2006/02/21 09:00 [pubmed]
PHST- 2006/06/17 09:00 [medline]
PHST- 2006/02/21 09:00 [entrez]
AID - S1095-6433(06)00028-6 [pii]
AID - 10.1016/j.cbpa.2006.01.014 [doi]
PST - ppublish
SO  - Comp Biochem Physiol A Mol Integr Physiol. 2006 Apr;143(4):494-503. doi: 
      10.1016/j.cbpa.2006.01.014. Epub 2006 Feb 20.