PMID- 16489401
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20060220
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 58
IP  - 1
DP  - 2006 Feb 25
TI  - [Long-term neurotoxic effects of MDMA result in cortical and hippocampal 
      structural changes].
PG  - 34-40
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a substituted amphetamine with 
      stimulating and hallucinogenic properties. Since MDMA induces "ecstasy" it is 
      extensively used as a "recreational" drug. It has been well established that MDMA 
      is neurotoxic and can result in long-term degeneration of cerebral 
      5-hydroxytryptamine (5-HT) nerve terminals in many species. The present study was 
      undertaken to investigate the long-term neurotoxic effects of MDMA on cortical 
      and hippocampal structures, by repeatedly administering MDMA in short time. Male 
      Wistar rats were randomly assigned to control group and MDMA-treated group. MDMA 
      (10 mg/kg) was administered to rats of MDMA-treated group, once per hour, total 
      40 mg/kg; rats of control group were treated with the same volume of saline. 
      Thirty-two weeks after administering MDMA, the expression of serotonin 
      transporter (SERT) mRNA and diazepam binding inhibitor (DBI) mRNA was detected by 
      in situ hybridization. The expression of glial fibrillary acidic protein (GFAP) 
      was detected by immunohistochemistry, and the degeneration of nerve terminals was 
      demonstrated by Bielschowsky and Glee Marsland silver staining. The results 
      showed that the expression of SERT mRNA in hippocampus decreased by 31.96%, while 
      expression of DBI mRNA in neocortex increased by 40.51%, compared with the 
      control group (P<0.05). The expression of GFAP in the brain tissue increased 
      (P<0.05), while significant reduction of the nerve terminals in neocortex was 
      demonstrated by silver staining, compared with the control group. These results 
      suggest that the neurotoxicity of MDMA results in sustained cortical and 
      hippocampal structural changes, which in turn result in disorder of the brain 
      functions.
FAU - Li, Su-Xia
AU  - Li SX
AD  - Basic and Forensic School, Sichuan University, Chengdu 610041, China.
FAU - Li, Jing
AU  - Li J
FAU - Wang, Xue
AU  - Wang X
FAU - Peng, Zu-Gui
AU  - Peng ZG
FAU - Kuang, Wei-Hong
AU  - Kuang WH
FAU - Huang, Ming-Sheng
AU  - Huang MS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Diazepam Binding Inhibitor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cerebral Cortex/*pathology/physiopathology
MH  - Diazepam Binding Inhibitor/genetics/metabolism
MH  - Hippocampus/*pathology/physiopathology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurotoxicity Syndromes/etiology/*pathology/physiopathology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin Plasma Membrane Transport Proteins/genetics/metabolism
EDAT- 2006/02/21 09:00
MHDA- 2013/12/18 06:00
CRDT- 2006/02/21 09:00
PHST- 2006/02/21 09:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2006/02/21 09:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 2006 Feb 25;58(1):34-40.